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MAB1155 Anti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2

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MAB1155
50 µg  
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      Replacement Information

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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, IP, IHC, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1155
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2
      Alternate Names
      • Inteferon alpha/beta receptor 2
      • IFN-R-2
      • IFN-alpha binding protein
      • IFN-alpha/beta receptor 2
      • Interferon alpha binding protein
      • Type I Interferon receptor 2
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.1% bovine serum albumin (BSA).
      Quality LevelMQ100
      Applications
      ApplicationAnti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2 is an antibody against Interferon-α/β Receptor Chain 2 for use in FC, IP, IH.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Immunohistochemistry
      • Affects Function
      Application NotesBiological Studies

      Immunoprecipitation: (1-5 μg/mL)

      Immunohistochemistry: (1μg/mL)

      Flow cytometry: (1 μg/10 mL - block cells with 50% human AB serum)

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenHuman Interferon alpha/beta Receptor Chain 2
      CloneMMHAR-2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReacts with Human Interferon alpha/beta Receptor Chain 2 (CD118). Antibody neutralizes human interferon alpha receptor, interacts with extracellular domain, binds to human interferon alpha receptor with high affinity, and blocks biological action of Type I interferons.
      IsotypeIgG2a
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IFNAR2
      • IFNABR
      • IFNARB
      UniProt Number
      UniProt SummaryFUNCTION: Associates with IFNAR1 to form the tyoe I interferon receptor. Receptor for interferons aplha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation.
      SIZE: 515 amino acids; 57,759 Da
      SUBCELLULAR LOCATION: Single-pass type I membrane protein.
      SIMILARITY: Belongs to the type II cytokine receptor family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C or below for retention of full activity, for up to 12 months. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB1155 04053252663758

      Documentation

      Anti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Interferon-α/β Receptor Chain 2 Antibody, clone MMHAR-2 Certificats d'analyse

      TitreNuméro de lot
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 3068541
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 2483184
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 MONOCLONAL ANTIBODY 3074961
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3170888 3170888
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3054659 3054659
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3199242 3199242
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3226586 3226586
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3243498 3243498
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3305181 3305181
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 - 3318628 3318628

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Targeting interferon response genes sensitizes aromatase inhibitor resistant breast cancer cells to estrogen-induced cell death.
      Choi, HJ; Lui, A; Ogony, J; Jan, R; Sims, PJ; Lewis-Wambi, J
      Breast cancer research : BCR  17  6  2015

      Afficher le résumé
      25588716 25588716
      Positive role of promyelocytic leukemia protein in type I interferon response and its regulation by human cytomegalovirus.
      Kim, YE; Ahn, JH
      PLoS pathogens  11  e1004785  2015

      Afficher le résumé
      25812002 25812002
      Chlamydia trachomatis-infected epithelial cells and fibroblasts retain the ability to express surface-presented major histocompatibility complex class I molecules.
      Kägebein, D; Gutjahr, M; Große, C; Vogel, AB; Rödel, J; Knittler, MR
      Infection and immunity  82  993-1006  2014

      Afficher le résumé
      24343651 24343651
      Gardiquimod: a Toll-like receptor-7 agonist that inhibits HIV type 1 infection of human macrophages and activated T cells.
      Buitendijk, M; Eszterhas, SK; Howell, AL
      AIDS research and human retroviruses  29  907-18  2013

      Afficher le résumé
      23316755 23316755
      Identification of a novel subunit of the type I interferon receptor localized to human chromosome 21.
      Colamonici, O R and Domanski, P
      J. Biol. Chem., 268: 10895-9 (1993)  1992

      Afficher le résumé
      8496154 8496154

      Fiche technique

      Titre
      MOUSE ANTI-HUMAN INTERFERON ALPHA/BETA RECEPTOR CHAIN 2 MONOCLONAL ANTIBODY

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies