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MAB2078Z Anti-Integrin α9β1 Antibody, clone Y9A2, azide free

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MAB2078Z
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Gp, HFC, IP, FUNCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2078Z
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Integrin α9β1 Antibody, clone Y9A2, azide free
      Alternate Names
      • MAB2078
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Control
      • Integrin alpha9beta1 positive tissues include basal keratinocytes, hepatocytes, muscle (smooth and skeletal), and airway epithelium.
      PresentationProtein A Purified mouse immunoglobulin in 20 mM sodium phosphate, 250 mM NaCl, pH. 7.6, with no preservatives.
      Quality LevelMQ100
      Applications
      ApplicationDetect Integrin α9β1 using this Anti-Integrin α9β1 Antibody, clone Y9A2, azide free validated for use in FC & IP.
      Key Applications
      • Flow Cytometry
      • Immunoprecipitation
      • Affects Function
      Applications Not Recommended
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunoprecipitation

      FACS Analysis

      Function blocking: 100% inhibition of alpha9beta1-mediated adhesion to the third fibronectin type III repeat in tenascin at <10 μg/mL.

      Not effective for immunohistochemistry, immunocytochemistry or western blot.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenMurine L cells transfected with human alpha9.
      CloneY9A2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityReactive with human and guinea pig alpha9beta1.
      IsotypeIgG1
      Species Reactivity
      • Guinea Pig
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes an alpha integrin. Integrins are heterodimeric integral membrane glycoproteins composed of an alpha chain and a beta chain that mediate cell-cell and cell-matrix adhesion. The protein encoded by this gene, when bound to the beta 1 chain, forms an integrin that is a receptor for VCAM1, cytotactin and osteopontin. Expression of this gene has been found to be upregulated in small cell lung cancers.
      Gene Symbol
      • ITGA9
      • RLC
      • ALPHA-RLC
      • ITGA4L
      Non-Reactive Species
      • Rat
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13797 # Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G- I-E-L in cytotactin.
      SIZE: 1035 amino acids; 114561 Da
      SUBUNIT: Heterodimer of an alpha and a beta subunit. Alpha-9 associates with beta-1.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: In airway epithelium, in the basal layer of squamous epithelium, and in smooth muscle, skeletal muscle, and hepatocytes. Abundantly expressed in fetal lung and lung cancers.
      SIMILARITY: SwissProt: Q13797 ## Belongs to the integrin alpha chain family. & Contains 7 FG-GAP repeats.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at 2–8°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB2078Z 04053252316005

      Documentation

      Anti-Integrin α9β1 Antibody, clone Y9A2, azide free FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Integrin α9β1 Antibody, clone Y9A2, azide free Certificats d'analyse

      TitreNuméro de lot
      Anti-Integrin #945;9#946;1, clone Y9A2, azide free - 2140031 2140031
      Anti-Integrin 91, clone Y9A2, azide free - 2112541 2112541
      Anti-Integrin 91, clone Y9A2, azide free - 2199610 2199610
      Anti-Integrin 91, clone Y9A2, azide free - 2299134 2299134
      Anti-Integrin 91, clone Y9A2, azide free - LV1739985 LV1739985
      Anti-Integrin 91, clone Y9A2, azide free - LV1786427 LV1786427
      Anti-Integrin 91, clone Y9A2, azide free - NG1873298 NG1873298
      Anti-Integrin α9β1, clone Y9A2, -2739315 2739315
      Anti-Integrin α9β1, clone Y9A2, -2757126 2757126
      Anti-Integrin α9β1, clone Y9A2, azide free - 3172464 3172464

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Migration-promoting role of VEGF-C and VEGF-C binding receptors in human breast cancer cells.
      Timoshenko, AV; Rastogi, S; Lala, PK
      British journal of cancer  97  1090-8  2007

      Afficher le résumé
      17912247 17912247
      Differential survival of leukocyte subsets mediated by synovial, bone marrow, and skin fibroblasts: site-specific versus activation-dependent survival of T cells and neutrophils.
      Filer, A; Parsonage, G; Smith, E; Osborne, C; Thomas, AM; Curnow, SJ; Rainger, GE; Raza, K; Nash, GB; Lord, J; Salmon, M; Buckley, CD
      Arthritis and rheumatism  54  2096-108  2005

      Afficher le résumé
      16802344 16802344
      Osteopontin N-terminal domain contains a cryptic adhesive sequence recognized by alpha9beta1 integrin.
      Smith, L L, et al.
      J. Biol. Chem., 271: 28485-91 (1996)  1996

      Afficher le résumé
      8910476 8910476
      Differential regulation of airway epithelial integrins by growth factors.
      Wang, A, et al.
      Am. J. Respir. Cell Mol. Biol., 15: 664-72 (1996)  1996

      Afficher le résumé
      8918373 8918373