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MABN450 Anti-GCM2 Antibody, clone 8A10.1

This Anti-GCM2 Antibody, clone 8A10.1 is validated for use in Western Blotting for the detection of GCM2.

Anti-GCM2 Antibody, clone 8A10.1 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: GCMB UniProt Number: O75603
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MABN450
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABN450
      DescriptionAnti-GCM2 Antibody, clone 8A10.1
      Alternate Names
      • hGCMb
      • Chorion-specific transcription factor GCMb
      • GCM2
      • GCM 2
      • GCM-2
      • GCM motif protein 2
      • Glial cells missing homolog 2
      Background InformationGCM2 is a nuclear protein that is involved in transcription regulation of many genes including ones important in parathyroid metabolism and development. Glial cells missing homolog 2 or GCM2 is expressed predominately in the pharyngeal pouches and, at later stages, in the developing and mature parathyroid glands. In humans, loss of GCM2 function, either through recessive apomorphic mutations or dominant inhibitor mutations in the human GCM2 gene, leads to isolated hypoparathyroidism. GCM2 expression is continued in the adult parathyroid at high levels and appears to be important in calcium sensing and calcium receptor expression in adult parathyroid cells.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-GCM2 Antibody, clone 8A10.1 is validated for use in Western Blotting for the detection of GCM2.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to Human GCM2.
      Clone8A10.1
      Concentration0.5 mg/mL
      HostMouse
      IsotypeIgMκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • GCMB
      UniProt Number
      Molecular Weight~ 58 kDa observed. An uncharacterized band appears at ~110 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SH-SY5Y cell lysate.

      Western Blotting Analysis: 0.5 µg/mL of this antibody detected GCM2 in 10 µg of SH-SY5Y cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABN450 04055977112726