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MABC289 Anti-FYVE (Alfy domain), clone 5B11.1 Antibody

Anti-FYVE (Alfy domain), clone 5B11.1 Antibody is an antibody against FYVE for use in Western Blotting and Immunocytochemistry, Immunoprecipitation.

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Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: WDFY3, KIAA0993 UniProt Number: Q8IZQ1
MABC289
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICC, IPMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC289
      DescriptionAnti-FYVE (Alfy domain), clone 5B11.1 Antibody
      Alternate Names
      • Autophagy-linked FYVE
      • FYVE (Alfy domain)
      • WD repeat and FYVE domain-containing protein 3
      • Autophagy-linked FYVE protein
      • Alfy
      Background InformationPhosphatidylinositol-3-phosphate [PtdIns(3)P] regulates endocytic and autophagic membrane traffic. PtdIns(3)P-binding proteins, many of which contain FYVE zinc-finger domains play important roles in the metabolism of PtdIns(3)P. The FYVE-protein Alfy, is a large, scaffolding, multi-domain, PtdIns(3)P binding protein that is implicated in autophagy trafficking. Alfy is widely expressed and localizes to the nuclear membranes during normal cell health but relocalizes to autophagic membranes and ubiquitin containing aggregates during cellular stress. Alfy is also a LC3 binding protein and binds GABARAPs too. Binding of Alfy to GABARAP is indispensable for its recruitment to LC3B-positive structures and thus, for the clearance of certain p62 structures by autophagy. Latest research indicates that Alfy is also important in regulating autophagy's role in various diseases including rheumatoid arthritis and neurological diseases.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ300
      Applications
      ApplicationAnti-FYVE (Alfy domain), clone 5B11.1 Antibody is an antibody against FYVE for use in Western Blotting and Immunocytochemistry, Immunoprecipitation.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: 2 µg/mL from a representative lot immunoprecipitated FYVE (Alfy domain) in 500 µg of HeLa cell lysate.
      Immunocytochemistry Analysis: 20 µg/mL from a representative lot detected FYVE (Alfy domain) in HeLa cells.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human FYVE (Alfy domain).
      Clone5B11.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • WDFY3
      • KIAA0993
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~200-240 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HeLa cell lysate.

      Western Blotting Analysis: 5.0 µg/mL of this antibody detected FYVE (Alfy domain) in 200 µg of HeLa cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABC289 04055977136289