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MAB2624 Anti-Endomucin Antibody, clone V.5C7

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MAB2624
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IP, IHC, FCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB2624
      DescriptionAnti-Endomucin Antibody, clone V.5C7
      Alternate Names
      • Endomucin-2
      • Gastric cancer antigen Ga34
      • Mucin-14
      • MUC-14
      • Endomucin-1/2
      Background InformationEndomucin is an endothelial sialomucin belonging to a class of glycoproteins characterized by their high levels of O-glycosolation and rich quantities of sialic acid. It inhibits focal adhesion assembly and hinders extracellular matrix and cell interaction. Observed expression is highest in kidney heart, brain, liver, lung, spleen, and thymus. Endomucin is only found in endothelial cells.
      Product Information
      FormatPurified
      Control
      • bEND3 cell lysate
      PresentationPurified rat monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Endomucin Antibody, clone V.5C7 detects level of Endomucin & has been published & validated for use in WB, IP, IH, FC.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunohistochemistry
      • Flow Cytometry
      Application NotesImmunoprecipitation Analysis: A previous lot was used by an independent laboratory in IP of bEND cell lysate (Morgan, 1999).

      Immunohistochemistry Analysis: A previous lot was used by an independent laboratory in immunhistochemical staining of frozen and paraffin-embedded tissue sections of mouse tongue, heart, uterus, brain, and small intestine (Morgan, 1999).

      Flow Cytometry Analysis: A previous lot was used by an independent laboratory in FC of transfected COS-7 cells (Morgan, 1999).
      Biological Information
      ImmunogenMouse endothelial cells
      CloneV.5C7
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      IsotypeIgG1κ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MUC14
      • EMCN2
      • MUC-14
      Purification MethodProtein G
      UniProt Number
      UniProt SummaryFUNCTION: Endothelial sialomucin, also called endomucin or mucin-like sialoglycoprotein, which interferes with the assembly of focal adhesion complexes and inhibits interaction between cells and the extracellular matrix (by similarity).

      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein Potential.

      TISSUE SPECIFICTY: Highly expressed in heart and kidney, followed by brain, spleen, thymus, liver and lung. Exclusively expressed in endothelial cells.

      PTM: Highly O-glycosylated. Sialic acid-rich glycoprotein.
      Molecular Weight ~ 75kDa observed
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot on mouse endothelioma cell line, bEND3, cell lysate.

      Western Blot Analysis: 0.0025 µg/mL of this antibody detected Endomucin in 10 µg of bEND3 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Référence GTIN
      MAB2624 04053252552397