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MAB4073 Anti-CD44v6 Antibody, exon v6, clone VFF-18

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MAB4073
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HFC, WB, ICC, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4073
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD44v6 Antibody, exon v6, clone VFF-18
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in PBS with no preservative.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-CD44v6 Antibody, exon v6, clone VFF-18 is validated for use in FC, WB, IC, IH(P) for the detection of CD44v6.
      Key Applications
      • Flow Cytometry
      • Western Blotting
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on acetone fixed cryostat sections using the alkaline phosphatase-anti-alkaline-phosphatase (APAAP) or peroxidase anti-peroxidase (PAP) procedures. Antibody may be used at a concentration of 1 - 2 μg/mL.

      Immunohistochemistry on paraffin embedded sections after microwave treatment (1 x 5 min). Antibody may be used at a concentration of 1 - 2 μg/mL.

      Immunocytochemistry on cell smears.

      Western blot

      Flow cytometry: 1:20 dilution

      Optimal working dilutions must be determined by end user.
      Biological Information
      Epitopeexon v6
      CloneVFF-18
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificitySpecific for an epitope encoded by exon v6 on the variant portion of human CD44.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis.
      Gene Symbol
      • CD44
      • LHR
      • HUTCH-I
      • CDW44
      • CDw44
      • ECMR-III
      • Epican
      • MGC10468
      • CD44R
      • PGP-1
      • MDU2
      • CSPG8
      • Pgp1
      • IN
      • MUTCH-I
      • MIC4
      • MDU3
      • MC56
      • HCELL
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P16070 # Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events.
      SIZE: 742 amino acids; 81554 Da
      SUBUNIT: Interacts with HA, as well as other glycosaminoglycans, collagen, laminin, and fibronectin via its N-terminal segment. Interacts with ANK, the ERM proteins (VIL2, RDX and MSN), and NF2 via its C-terminal segment.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      TISSUE SPECIFICITY: An epithelial isoform (CD44E) is expressed by cells of epithelium and highly expressed by carcinomas. An hematopoietic isoform (CD44H) is expressed by cells of mesodermal origin. Expression is repressed in neuroblastoma cells.
      PTM: Proteolytically cleaved in the extracellular matrix by specific proteinases (possibly MMPs) in several cell lines and tumors. & N-glycosylated. & O-glycosylated; contains more-or-less-sulfated chondroitin sulfate glycans, whose number may affect the accessibility of specific proteinases to their cleavage site(s). & Phosphorylated; activation of PKC results in the dephosphorylation of Ser-706 (constitutive phosphorylation site), and the phosphorylation of Ser-672.
      SIMILARITY: SwissProt: P16070 ## Contains 1 Link domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C in undiluted aliquots for up to 12 months from date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Référence GTIN
      MAB4073 04053252578571