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MABS453 Anti-Axin2, clone cond4-1D5 Antibody

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MABS453
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, ICCRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABS453
      DescriptionAnti-Axin2, clone cond4-1D5 Antibody
      Alternate Names
      • Axin-2
      • Axin-like protein
      • Axil
      • Conductin
      Background InformationAxin-2, or Axis inhibition protein 2, is an inhibitor of the Wnt signaling pathway that down-regulates beta-catenin and APC through phosphorylation. Axin-2 abnormalities are linked to defective mismatch repair and have been found to be involved in colorectal cancer (CRC) and oligodontia-colorectal cancer syndrome (ODCRCS). Axin-2 can be found in brain and lymphoblast tissues.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Axin2, clone cond4-1D5 Antibody is validated for use in Western Blotting and Immunocytochemistry for the detection of Axin2.
      Key Applications
      • Western Blotting
      • Immunocytochemistry
      Application NotesImmunocytochemistry Analysis: 20 μg/mL of this antibody from a representative lot detected Axin2 in HeLa, HEK293 and NIH-3T3 cells.
      Western Blotting Analysis: A representative lot of this antibody detected Axin2 in SW 480 cell lines
      Biological Information
      ImmunogenLinear peptide corresponding to Human Axin 2.
      Clonecond4-1D5
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      SpecificityThis monoclonal antibody recognizes both endogeneous and overexpressed Axin2 and does not cross-react with Axin1
      IsotypeIgG2aκ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Axin2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight~ 95 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in HCT116 cell lysate.

      Western Blotting Analysis: 1 μg/mL of this antibody detected Axin2 in 10 µg of HCT116 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABS453 04055977109368

      Documentation

      Anti-Axin2, clone cond4-1D5 Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-Axin2, clone cond4-1D5 Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-Axin2, clone cond4-1D5 Q2470584
      Anti-Axin2, clone cond4-1D5 - 3188585 3188585
      Anti-Axin2, clone cond4-1D5 - 3859709 3859709
      Anti-Axin2, clone cond4-1D5 - 4108571 4108571
      Anti-Axin2, clone cond4-1D5 -2786919 2786919
      Anti-Axin2, clone cond4-1D5 Monoclonal Antibody 3096475

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Expression and localization of axin 2 in colorectal carcinoma and its clinical implication.
      Schaal, U; Grenz, S; Merkel, S; Rau, TT; Hadjihannas, MV; Kremmer, E; Chudasama, P; Croner, RS; Behrens, J; Stürzl, M; Naschberger, E
      International journal of colorectal disease  28  1469-78  2013

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      23702820 23702820