Millipore Sigma Vibrant Logo

119137 Adenosine A2A Receptor Agonist I, CGS 21680, Hydrochloride - CAS 124182-57-6 - Calbiochem

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: CGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid

View Products on Sigmaaldrich.com
119137
Voir les Prix & la Disponibilité

Aperçu

Prix & Disponibilité

Référence DisponibilitéConditionnement Qté Prix Quantité
119137-5MG
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      		 Flacon en verre 5 mg
      Le prix n'a pas pu être récupéré
      La quantité minimale doit être un multiple de
      Maximum Quantity is
      À la validation de la commande Plus d'informations
      Vous avez sauvegardé ()
       
      —
      Demander le prix
      		 —
      Ajouter aux favoris
      Description
      OverviewA xanthin derivative that acts as a potent agonist of adenosine A2A receptors (Ki = 27 nM). Exhibits reduced affinity for A2B receptors (Ki = 67 nM), but offers greater selectivity over A1R (Ki = 290 nM) and A3R (88.8 µM). Exerts an anti-inflammatory effect during chronic inflammation and ameliorates the tissue damage associated with collagen-induced arthritis. Also shown to reduce CCR7 Protein Expression in THP1 macrophages. Shown to delay the progressive deterioration of motor performance and prevent a reduction in brain weight in murine model of Huntington's disease. Please note that the molecular weight for this compound is batch-specific due to variable water content. Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight. The molecular weight provided represents the baseline molecular weight without water.
      Catalogue Number119137
      Brand Family Calbiochem®
      SynonymsCGS-21680, CGS21680, 3-(4-(2-((6-amino-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxytetrahydrofuran-2-yl)-9H-purin-2-yl)amino)ethyl)phenyl)propanoic acid
      References
      ReferencesWillians, A. J., et al. 2012. Inflammation. 35, 614.
      Mazzon, E. et al. 2011. J Rheumatol. 38, 2119,
      Martire, A., et al. 2007. Neurosci Lett. 417, 78.
      Chou, S. Y., et al, 2005. Journ Neurochem. 93, 310.
      Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol.362 382.
      Phillis, J. W., et al. 1990.Brain Res. 509, 328.
      Product Information
      CAS number124182-57-6
      FormWhite solid
      FormulationSupplied as a hydrochloride salt.
      Hill FormulaC₂₃H₂₉N₇O₆ • HCl
      Chemical formulaC₂₃H₂₉N₇O₆ • HCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥96% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      119137-5MG 04055977223330