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119136 Adenosine A1 Receptor Agonist II, CCPA - CAS 37739-05-2 - Calbiochem

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119136-10MG
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      Description
      OverviewAn adenosine analog that acts as a selective, high affinity agonist for Adenosine A1 receptor (A1R) (Ki = 800 pM; 2.3 µM, 18.8 µM, and 42 nM for human A1, A2A, A2B, A3 respectively). Shown to be centrally active following systemic administration and exhibits anti-convulsive effects. Also reported to inhibit adenylate cyclase activity in rat fat cell membrane (IC50 = 33 nM). Diminishes respiratory rhythm, reduces heart rate, and enhances the activity of KATP channels. Reduces norepinephrine release by about 50% in untreated and pertussis toxin treated hearts.
      Catalogue Number119136
      Brand Family Calbiochem®
      Synonyms(2R,3R,4S,5R)-2-(2-chloro-6-(cyclopentylamino)-9H-purin-9-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol, 2-Chloro-N6-cyclopentyladenosine
      References
      ReferencesBurgdorf, C. et al. 2005. J Cardiovasc Pharmacol. 45, 1.
      Klotz, K. N., et al. 2000. Naunyn Schmiedebergs Arch Pharmacol. 362, 382.
      Mironov, S., et al. 1990. J Neurophysiol. 81, 1.
      Monopoli, A., et al. 1994.Arzneimittelforschung. 44, 1305.
      Concas, A., et al. 1993. J Pharmacol Exp Ther. 267, 844.
      Lohse, M. J., et al. 1988. Nauryn Schmiedebergs Arch Pharmacol. 337, 687.
      Coffin, V. L., et al. 1987. J Pharmacol Exp Ther. 241, 76.
      Product Information
      CAS number37739-05-2
      FormWhite solid
      Hill FormulaC₁₅H₂₀ClN₅O₄
      Chemical formulaC₁₅H₂₀ClN₅O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetA1
      Primary Target K<sub>i</sub>2.3 nM
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Référence GTIN
      119136-10MG 04055977223323