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565773 γ-Secretase Inhibitor XII - Calbiochem

γ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.

γ-Secretase Inhibitor XII - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Z-IL-CHO

Primary Target: Aβ40 in vitro
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565773
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₂₀H₃₀N₂O₄

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565773-5MG
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      Description
      OverviewA cell-permeable, reversible dipeptide aldehyde that reduces Aβ production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured CHO 2b-7 cells that stably overexpress APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also blocks the generation of CTFγ (γ-secretase-generated carboxyl-terminal fragment). Does not affect the formation of amyloid-β-precursor protein (APP).
      Catalogue Number565773
      Brand Family Calbiochem®
      SynonymsZ-IL-CHO
      References
      ReferencesWeijzen, S., et al. 2002. Nat. Med. 8, 979.
      McLendon, C., et al. 2000. FASEB J. 14, 2383.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₀H₃₀N₂O₄
      Chemical formulaC₂₀H₃₀N₂O₄
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Applicationγ-Secretase Inhibitor XII, is a cell-permeable, reversible inhibitor of γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in APP695 expressing CHO 2b-7 cells.
      Biological Information
      Primary TargetAβ40 in vitro
      Primary Target IC<sub>50</sub>7.9 µM for Aβ40; 7.6 µM for Aβ42 in vitro
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Ile-Leu-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      565773-5MG 04055977267860

      Documentation

      γ-Secretase Inhibitor XII - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      γ-Secretase Inhibitor XII - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      565773

      Références bibliographiques

      Aperçu de la référence bibliographique
      Weijzen, S., et al. 2002. Nat. Med. 8, 979.
      McLendon, C., et al. 2000. FASEB J. 14, 2383.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-September-2008 RFH
      SynonymsZ-IL-CHO
      DescriptionA cell-permeable, reversible dipeptide aldehyde that reduces amyloid-β protein (Aβ) production by blocking γ-secretase activity in vitro (Aβ40 IC50 = 7.9 µM; Aβ42 IC50 = 7.6 µM) and in cultured cells that stably over-express APP695 (Aβ40 IC50 = 11.5 µM; Aβ42 IC50 = 8.3 µM). Also shown to block the generation of γCTF (γ-secretase-generated carboxy-terminal fragment).
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₀H₃₀N₂O₄
      Peptide SequenceZ-Ile-Leu-CHO
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWeijzen, S., et al. 2002. Nat. Med. 8, 979.
      McLendon, C., et al. 2000. FASEB J. 14, 2383.