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616467 Transglutaminase 2 Inhibitor, ZDON - Calbiochem

A cell-permeable, peptide-based, irreversible inhibitor of transglutaminase 2 (TG2; IC₅₀ = 150 nM for recombinant TG2). Reacts with the active site cysteine of TG2.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Z-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor

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616467
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₃₁H₄₅N₇O₉

Pricing & Availability

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616467-5MG
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      Description
      OverviewA cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
      Catalogue Number616467
      Brand Family Calbiochem®
      SynonymsZ-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
      References
      ReferencesMcConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.
      Product Information
      FormOff-white powder
      Hill FormulaC₃₁H₄₅N₇O₉
      Chemical formulaC₃₁H₄₅N₇O₉
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      616467-5MG 04055977185973

      Documentation

      Transglutaminase 2 Inhibitor, ZDON - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Transglutaminase 2 Inhibitor, ZDON - Calbiochem Certificates of Analysis

      TitleLot Number
      616467

      References

      Reference overview
      McConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-April-2014 JSW
      SynonymsZ-DON, 6-diazo-5-oxo-norleucine tetrapeptide, TG2 Inhibitor
      DescriptionA cell-permeable, peptide-based (Z- QVPL) irreversible inhibitor of transglutaminase 2 (TG2) (IC50 = 150 nM for recombinant TG2) that acts by reacting with the active site cysteine of TG2. Exhibits far less potency against TG1 and TG3. Shown to significantly increase PGC-1a and cytochrome c mRNA levels in Q7 and Q111 cells (~50 mM). Also shown to enhance cytochrome c promoter activity by 250% in Q111 cells. Exhibits protective effect in cells exposed to 3-nitropropionic acid and NMDA, however, it does not directly affect mitochondrial bioenergetics.
      FormOff-white powder
      Chemical formulaC₃₁H₄₅N₇O₉
      Purity≥98% by HPLC
      SolubilityDMSO (50 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesMcConoughey, S. J., et al. 2010. EMBO Mol. Medicine. 2, 349.