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GF037 Thrombopoietin

TPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation & maturation of megakaryocytes & promotes increased circulating levels of platelets in vivo.

Thrombopoietin MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Cell Culture UniProt Number: P40225 Entrez Gene Number: NM_199228.1, NM_199356.1, NM_000460.2
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GF037
10 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Key ApplicationsSpeciesSourcePurity
      CULTHuman E.coliGreater than 98% by SDS-PAGE and HPLC analyses. . Endotoxin level is less than 0.1 ng per mg (1 EU/μg) of human TPO.
      Description
      Catalogue NumberGF037
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionThrombopoietin
      OverviewTPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation and maturation of megakaryocytes and promotes increased circulating levels of platelets in vivo. Chemicon's Human TPO is a soluble 18.5 kDa protein containing 174 amino acid residues which comprises the receptor binding domain of the Mpl-ligand protein.
      Alternate Names
      • TPO
      References
      Product Information
      PresentationLyophilized protein from 5mM Tris, pH 7.6, with no additives.
      Quality LevelMQ100
      Applications
      ApplicationTPO (Thrombopoietin, Mpl-ligand, MGDF) stimulates the proliferation & maturation of megakaryocytes & promotes increased circulating levels of platelets in vivo.
      Key Applications
      • Cell Culture
      Biological Information
      PurityGreater than 98% by SDS-PAGE and HPLC analyses. . Endotoxin level is less than 0.1 ng per mg (1 EU/μg) of human TPO.
      SourceE.coli
      Specific ActivityThe ED50 was determined by the dose-dependent stimulation of the proliferation of M07e cells is <=1.0 ng/mL, corresponding to a specific activity of >=1x10(e6) units/mg.
      Entrez Gene Number
      Entrez Gene SummaryMegakaryocytopoiesis is the cellular development process that leads to platelet production. The protein encoded by this gene is a humoral growth factor that is necessary for megakaryocyte proliferation and maturation, as well as for thrombopoiesis. This protein is the ligand for MLP/C_MPL, the product of myeloproliferative leukemia virus oncogene.
      Gene Symbol
      • THPO
      • TPO
      • MGC163194
      • MPLLG
      • thrombopoietin
      • MGDF
      • ML
      • MKCSF
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P40225 # Lineage-specific cytokine affecting the proliferation and maturation of megakaryocytes from their committed progenitor cells. It acts at a late stage of megakaryocyte development. It may be the major physiological regulator of circulating platelets.
      SIZE: 353 amino acids; 37823 Da
      SUBCELLULAR LOCATION: Secreted.
      DOMAIN: SwissProt: P40225 Two-domain structure with an erythropoietin-like N- terminal and a Ser/Pro/Thr-rich C-terminal.
      DISEASE: SwissProt: P40225 # Defects in THPO are a cause of essential thrombocythemia (ET) [MIM:187950]. ET is inherited as an autosomal dominant trait which is characterized by elevated platelet levels due to sustained proliferation of megakaryocytes, and frequently lead to thrombotic and haemorrhagic complications.
      SIMILARITY: Belongs to the EPO/TPO family.
      Stem Cell Type
      • Hematopoietic Stem Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe lyophilized powder, though stable at room temperature, is best stored at -20°C. Reconstitute in 5 mM Tris, pH 8.0 to a concentration of 0.5-1.0 mg/mL. This solution can be diluted into other aqueous buffers and stored at 4ºC for 1 week or -20ºC for future use. Reconstituted TPO should be stored in working aliquots at -20°C.
      Packaging Information
      Material Size10 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      GF037 08436037125003

      Documentation

      Thrombopoietin SDS

      Title

      Safety Data Sheet (SDS) 

      Thrombopoietin Certificates of Analysis

      TitleLot Number
      RECOMBINANT HUMAN THROMBOPOIETIN 2462796
      RECOMBINANT HUMAN THROMBOPOIETIN 2991003
      RECOMBINANT HUMAN THROMBOPOIETIN - 2121736 2121736
      RECOMBINANT HUMAN THROMBOPOIETIN - 2012361 2012361
      RECOMBINANT HUMAN THROMBOPOIETIN - 2025949 2025949
      RECOMBINANT HUMAN THROMBOPOIETIN - 2048774 2048774
      RECOMBINANT HUMAN THROMBOPOIETIN - 2089385 2089385
      RECOMBINANT HUMAN THROMBOPOIETIN - 2196002 2196002
      RECOMBINANT HUMAN THROMBOPOIETIN - 2271152 2271152
      RECOMBINANT HUMAN THROMBOPOIETIN - 2352339 2352339
      Show more

      Data Sheet

      Title
      RECOMBINANT HUMAN THROMBOPOIETIN

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      Categories

      Life Science Research > Proteins and Enzymes > Cytokines & Growth Factors
      Life Science Research > Cell Culture and Systems > Cell Culture Media and Supplements > Cell Culture Supplements > Cytokines & Growth Factors