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605197 Thrombin-Activatable Fibrinolysis Inhibitor, Human

The Thrombin-Activatable Fibrinolysis Inhibitor, Human controls the biological activity of Thrombin-Activatable Fibrinolysis. This small molecule/inhibitor is primarily used for Biochemicals applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Plasma Procarboxypeptidase B, TAFI

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605197
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Overview

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605197-50UG
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      		 Plastic ampoule 50 μg
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      Description
      OverviewNative thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. Circulates in plasma as a zymogen at a concentration of 50 nM. Activated by thrombin-thrombomodulin complex by proteolytic cleavage at Arg92. Believed to play an important role in interaction between the procoagulant, anticoagulant, and fibrinolytic systems.
      Catalogue Number605197
      Brand Family Calbiochem®
      SynonymsPlasma Procarboxypeptidase B, TAFI
      References
      ReferencesBoffa, M.B., et al. 1999. Biochemistry 38, 6547.
      Boffa, M.B., et al. 1998. J. Biol. Chem. 273, 2127.
      Bajzar, L., et al. 1995. J. Biol. Chem. 270, 14477.
      Product Information
      Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1 µM Hip-L-Arg per min at 25°C, pH 7.65.
      FormLiquid
      FormulationIn 150 mM NaCl, 20 mM HEPES, pH 7.4.
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by SDS-PAGE
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Specific Activity≥2-9 units/mg protein
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      605197-50UG 04055977188431

      Documentation

      Thrombin-Activatable Fibrinolysis Inhibitor, Human SDS

      Title

      Safety Data Sheet (SDS) 

      Thrombin-Activatable Fibrinolysis Inhibitor, Human Certificates of Analysis

      TitleLot Number
      605197

      References

      Reference overview
      Boffa, M.B., et al. 1999. Biochemistry 38, 6547.
      Boffa, M.B., et al. 1998. J. Biol. Chem. 273, 2127.
      Bajzar, L., et al. 1995. J. Biol. Chem. 270, 14477.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-November-2007 JSW
      SynonymsPlasma Procarboxypeptidase B, TAFI
      DescriptionNative thrombin-activatable fibrinolysis inhibitor from human liver. Single chain glycoprotein synthesized in the liver. ctivated by the thrombin/thrombomodulin complex by proteolytic cleavage at Arg92. Circulates in plasma as a zymogen at a concentration of about 50 nM. Believed to play an important role in the interaction between procoagulant, anticoagulant, and fibrinolytic systems.
      FormLiquid
      FormulationIn 150 mM NaCl, 20 mM HEPES, pH 7.4.
      Concentration Label Please refer to vial label for lot-specific concentration
      SourcePrepared from serum that has been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
      Purity≥95% by SDS-PAGE
      Specific activity≥2-9 units/mg protein
      Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1 µM Hip-L-Arg per min at 25°C, pH 7.65.
      Storage ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesBoffa, M.B., et al. 1999. Biochemistry 38, 6547.
      Boffa, M.B., et al. 1998. J. Biol. Chem. 273, 2127.
      Bajzar, L., et al. 1995. J. Biol. Chem. 270, 14477.