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566660 Smoothened Agonist, SAG - CAS 364590-63-6 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
364590-63-6C₂₈H₂₈ClN₃OS • 2HCl • 2H₂O

Pricing & Availability

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566660-1MG
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      566660-5MG
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          Description
          OverviewA cell-permeable benzothiophene compound that modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). Shown to induce Smo internalization. Shown to induce Hedgehog pathway activation (EC50 = ∼ 3 nM in NIH 3T3-derived Shh-LIGHT2 cells) and counteracts Cyclopamine-KAAD (Cat. No. 239804) inhibition of Smo. Reported to act as an activator at low concentrations and as an inhibitor at very high concentrations. A 10 mM (500 µg/86 µl) solution of Smoothened Agonist, SAG (Cat. No. 566661) in H2O is also available.
          Catalogue Number566660
          Brand Family Calbiochem®
          SynonymsN-Methyl-Nʹ-(3-pyridinylbenzyl)-Nʹ-(3-chlorobenzo[b]thiophene-2-carbonyl)-1,4-diaminocyclohexane, SAG1.3
          References
          ReferencesWang, J., et al. 2010. Proc. Natl. Acad. Sci. USA. 107, 9323.
          Meloni, A.R., et al. 2006. Mol. Cell. Biol. 26, 7750.
          Chen, W., et al. 2004. Science 306, 2257.
          Chen, J.K., et al. 2002. Proc. Natl. Acad. Sci. USA 99, 14071.
          Frank-Kamenetsky, M., et al. 2002. J. Biol. 1, 10.
          Product Information
          CAS number364590-63-6
          FormLight yellow solid
          Hill FormulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
          Chemical formulaC₂₈H₂₈ClN₃OS • 2HCl • 2H₂O
          Hygroscopic Hygroscopic
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Biological Information
          Purity≥98% by HPLC
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Protect from Light Protect from light
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Global Trade Item Number
          Catalogue Number GTIN
          566660-1MG 07790788051570
          566660-5MG 04055977191578