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573096 STAT3 Inhibitor Peptide, Cell-Permeable

STAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.

STAT3 Inhibitor Peptide, Cell-Permeable MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: PpYLKTK-mts, STAT3 Inhibitor IV

Primary Target: Blocker of Stat3 activation
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573096
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Overview

Replacement Information

Key Spec Table

Empirical Formula
C₉₂H₁₅₇N₂₀O₂₄P

Pricing & Availability

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573096-1MG
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      		 Plastic ampoule 1 mg
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      573096-5MG
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      Discontinued
      Limited Quantities Available
      Availability to be confirmed
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          		 Plastic ampoule 5 mg
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          Description
          OverviewA cell-permeable analog of the Stat3-SH2 domain-binding phosphopeptide (Cat. No. 573095) that contains a C-terminal mts (membrane translocating sequence) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat-3 dependent Src transformation with no effect on Stat-3 independent Ras transformation. The unphosphorylated inactive control peptide is also available under Cat. No. 573105.
          Supplied as a trifluoroacetate salt.
          Catalogue Number573096
          Brand Family Calbiochem®
          SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
          References
          ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
          Product Information
          ATP CompetitiveN
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Hill FormulaC₉₂H₁₅₇N₂₀O₂₄P
          Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
          Hygroscopic Hygroscopic
          ReversibleN
          Quality LevelMQ100
          Applications
          ApplicationSTAT3 Inhibitor Peptide, Cell-Permeable, is an analog of Stat3-SH2 domain-binding phosphopeptide with a C-terminal membrane translocating sequence. A selective, potent blocker of Stat3 activation.
          Biological Information
          Primary TargetBlocker of Stat3 activation
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Standard Handling
          Storage -20°C
          Hygroscopic Hygroscopic
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Catalogue Number GTIN
          573096-1MG 07790788051730
          573096-5MG 07790788051747

          Documentation

          STAT3 Inhibitor Peptide, Cell-Permeable SDS

          Title

          Safety Data Sheet (SDS) 

          STAT3 Inhibitor Peptide, Cell-Permeable Certificates of Analysis

          TitleLot Number
          573096

          References

          Reference overview
          Turkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.

          Brochure

          Title
          An Introduction to Inhibitors and Their Biological Applications - 1st Edition

          Technical Info

          Title
          JAK/STAT Signaling Research Focus

          Citations

          Title
        • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
        • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
        • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
          		•
          Data Sheet

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision12-September-2008 RFH
          SynonymsPpYLKTK-mts, STAT3 Inhibitor IV
          DescriptionA cell-permeable analog of the Stat3-SH2 domain-binding phospho-peptide (Cat. No. 573095) that contains a C-terminal membrane translocating sequence (MTS) and acts as a highly selective, potent blocker of Stat3 activation. Also suppresses constitutive Stat3-dependent Src transformation with no effect on Stat3-independent Ras transformation.
          FormWhite lyophilized solid
          FormulationSupplied as a trifluoroacetate salt.
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₉₂H₁₅₇N₂₀O₂₄P
          Peptide SequenceH-Pro-Tyr-(PO₃H₂)-Leu-Lys-Thr-Lys-Ala-Ala-Val-Leu-Leu-Pro-Val-Leu-Leu-Ala-Ala-Pro-OH
          Purity≥95% by HPLC
          SolubilityH₂O (1 mg/ml)
          Storage -20°C
          Hygroscopic
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
          Toxicity Standard Handling
          ReferencesTurkson, J., et al. 2001. J. Biol. Chem. 276, 45443.
          Rojas, M., et al. 1998. Nat. Biotechnol. 16, 370.
          Citation
        • Rob D. Catalano, et al. (2005) Inhibition of STAT3 activation in the endometrium prevents implantation: a nonsteroidal approach to contraception. Proceedings of the National Academy of Science USA in press,.
        • Yoshinari Tanabe, et al. (2005) Role of STAT1, STAT3, and STAT5 in IFN-αβ responses in T lymphocytes. Journal of Immunology 174, 609-613.
        • Egle Avizienyte, et al. (2004) Src SH3/2 domain-mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition. Molecular Biology of the Cell 15, 2794-2803.
          		•