Our broad portfolio consists of multiplex panels that allow you to choose, within the panel, analytes that best meet your needs. On a separate tab you can choose the premixed cytokine format or a single plex kit.
Cell Signaling Kits & MAPmates™
Choose fixed kits that allow you to explore entire pathways or processes. Or design your own kits by choosing single plex MAPmates™, following the provided guidelines.
The following MAPmates™ should not be plexed together:
-MAPmates™ that require a different assay buffer
-Phospho-specific and total MAPmate™ pairs, e.g. total GSK3β and GSK3β (Ser 9)
-PanTyr and site-specific MAPmates™, e.g. Phospho-EGF Receptor and phospho-STAT1 (Tyr701)
-More than 1 phospho-MAPmate™ for a single target (Akt, STAT3)
-GAPDH and β-Tubulin cannot be plexed with kits or MAPmates™ containing panTyr
.
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To begin designing your MILLIPLEX® MAP kit select a species, a panel type or kit of interest.
Custom Premix Selecting "Custom Premix" option means that all of the beads you have chosen will be premixed in manufacturing before the kit is sent to you.
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Add Additional Reagents (Buffer and Detection Kit is required for use with MAPmates)
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48-602MAG
Buffer Detection Kit for Magnetic Beads
1 Kit
Space Saver Option Customers purchasing multiple kits may choose to save storage space by eliminating the kit packaging and receiving their multiplex assay components in plastic bags for more compact storage.
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506272
Sigma-AldrichSB 206553 Hydrochloride - CAS 158942-04-2 - Calbiochem
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Description
Overview
A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
Data Sheet
Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
A selective 5-HT2C serotonin receptor inhibitor with lesser affinity for 5-HT2BR. Often used in conjunction with ketanserin to distinguish 5-HT2AR and 5-HT2CR activity. SB206553 has highest affinity for 5-HT2CR (Ki = 3.2nM) and less for 5-HT2BR (Ki = 5.5 nM) and 5-HT2AR (Ki = 2,300 nM).
Form
Yellow solid
CAS number
158942-04-2
Chemical formula
C₁₇H₁₆N₄O·HCl
Structure formula
Purity
≥99% by HPLC
Solubility
DMSO
Storage
Protect from light +2°C to +8°C
Do Not Freeze
Ok to freeze
Special Instructions
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity
Standard Handling
References
Ros, R. et al. 2013. PNAS.110, 348. Knight, A. R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114. Cussac, D. et al. 2002. Naunyn Schmiedebergs Arch. Pharmacol.365, 242.
