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552233 QX-314 - CAS 21306-56-9 - Calbiochem

A quaternary lidocaine derivative, permanently charged, and lipophobic.

QX-314 - CAS 21306-56-9 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: A powerful blocker of voltage-sensitive Na+ conductance
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552233
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
21306-56-9C₁₆H₂₇BrN₂O

Pricing & Availability

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552233-100MG
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      Description
      OverviewA quaternary lidocaine derivative, permanently charged, and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
      Catalogue Number552233
      Brand Family Calbiochem®
      References
      ReferencesMooney, R. 1992. J. Neurosci. 12, 2464.
      Regehr, W.G. and Tank, D.W. 1992. J. Neurosci. 12, 4202.
      Product Information
      CAS number21306-56-9
      ATP CompetitiveN
      FormLyophilized solid
      Hill FormulaC₁₆H₂₇BrN₂O
      Chemical formulaC₁₆H₂₇BrN₂O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityfully active in neurophysiological testing
      Primary TargetA powerful blocker of voltage-sensitive Na+ conductance
      Purity≥99%
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 36/37/38

      Irritating to eyes, respiratory system and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +15°C to +30°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      552233-100MG 04055977268331

      Documentation

      QX-314 - CAS 21306-56-9 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      QX-314 - CAS 21306-56-9 - Calbiochem Certificates of Analysis

      TitleLot Number
      552233

      References

      Reference overview
      Mooney, R. 1992. J. Neurosci. 12, 2464.
      Regehr, W.G. and Tank, D.W. 1992. J. Neurosci. 12, 4202.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-June-2018 JSW
      DescriptionA quaternary lidocaine derivative, permanently charged and lipophobic. A powerful blocker of voltage-sensitive Na+ conductance when applied intracellularly. Suppresses the generation of Na+-dependent spikes from inside the cell membrane, without affecting Ca2+ currents or glutamate-activated currents.
      FormLyophilized solid
      CAS number21306-56-9
      Chemical formulaC₁₆H₂₇BrN₂O
      Structure formulaStructure formula
      Purity≥99%
      Biological activityfully active in neurophysiological testing
      SolubilityH₂O (3 mg/ml)
      Storage Protect from light
      +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 weeks at 4°C.
      Toxicity Irritant
      ReferencesMooney, R. 1992. J. Neurosci. 12, 2464.
      Regehr, W.G. and Tank, D.W. 1992. J. Neurosci. 12, 4202.