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508514 Psalmotoxin-1 - CAS 316808-68-1 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
316808-68-1 C₂₀₀H₃₁₂N₆₂O₅₇S₆

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5085140001
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      Glass bottle 20 μg
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      Description
      OverviewA potent proton-gated sodium channel (ASIC1a) channel blocking neurotoxin (IC50 = 0.9 nm) isolated from the Trinidad chevron tarantula. Psalmotoxin-1 (PcTx1) can distinguish between the two ASIC1 splice variants, ASIC1a and ASIC1b. Binding site is blocked when dimerization with ASIC2a or ASIC3.
      Catalogue Number508514
      Brand Family Calbiochem®
      SynonymsASIC1a Inhibitor, Psalmotoxin 1
      References
      ReferencesQadri, Y. J. et al. 2009. J. Biol. Chem. 284, 17625.
      M. Mazzuca, et al. 2007. Nat Neurosci. 10, 943.
      Escoubas, P. et al. 2000. J. Biol. Chem. 275, 25116.
      Product Information
      CAS number316808-68-1
      FormColorless semi-solid to viscous liquid
      Hill Formula C₂₀₀H₃₁₂N₆₂O₅₇S₆
      Chemical formulaC₂₀₀H₃₁₂N₆₂O₅₇S₆
      Hygroscopic Hygroscopic
      Quality LevelMQ100
      Biological Information
      Primary TargetASIC1a
      Primary Target IC<sub>50</sub>0.9 nM
      Purity≥94% by HPLC
      Physicochemical Information
      Peptide SequenceEDCIPKWKGCVNRHGDCCEGLECWKRRRSFEVCVPKTPKT (disulfide bond 3-18, 10-23, 17-33)
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      5085140001 04055977262056