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539741 PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem

PTP1B Inhibitor, CAS 765317-72-4, is a cell-permeable, selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC₅₀ = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII

Primary Target: PTP1B403
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539741
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
765317-72-4C₂₆H₁₉Br₂N₃O₇S₃

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539741-5MG
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      Description
      OverviewA cell-permeable sulfanamido-benzbromarone compound that acts as a selective, reversible and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749).
      Catalogue Number539741
      Brand Family Calbiochem®
      Synonyms3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
      References
      ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
      Product Information
      CAS number765317-72-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₁₉Br₂N₃O₇S₃
      Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPTP1B403
      Primary Target IC<sub>50</sub> 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      539741-5MG 04055977194302

      Documentation

      PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PTP1B Inhibitor - CAS 765317-72-4 - Calbiochem Certificates of Analysis

      TitleLot Number
      539741

      References

      Reference overview
      Wiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-January-2012 RFH
      Synonyms3-(3,5-Dibromo-4-hydroxy-benzoyl)-2-ethyl-benzofuran-6-sulfonicacid-(4-(thiazol-2-ylsulfamyl)-phenyl)-amide, PTP Inhibitor XXII
      DescriptionA cell-permeable, selective, reversible, and non-competitive allosteric inhibitor of PTP1B (IC50 = 4 µM and 8 µM for PTP1B403 and PTP1B298, respectively). Binds to a novel site away from the catalytic pocket and inhibits PTP1B activity by preventing closure of the WPD loop. Also available in InSolution™ format (Cat. No. 539749.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number765317-72-4
      Chemical formulaC₂₆H₁₉Br₂N₃O₇S₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesWiesmann, C., et al. 2004. Nat. Struct. Mol. Biol. 11, 730.