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550602 PKM2 Activator II, DASA - CAS 1186654-00-1 - Calbiochem

PKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: Pyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine

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550602
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Overview

Key Spec Table

CAS #Empirical Formula
1186654-00-1C₁₈H₁₈F₂N₂O₆S₂

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550602-10MG
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      Description
      OverviewA cell-permeable diarylsulfonamide (DASA) compound that acts as a potent and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM). Pretreatment of A549 (adenocarcinomic human alveolar basal epithelial cells) with DASA-10 (~10 µM) prevents hydrogen peroxide, diamide, and hypoxia-induced inactivation of PKM2. DASA treatment is shown to cause a diminution in cellular glutathione levels, and higher oxidative stress-induced cell death.
      Catalogue Number550602
      Brand Family Calbiochem®
      SynonymsPyruvate Kinase M2 Activator II, 1-(2,6-Difluorophenylsulfonyl)-4-(2,3-dihydrobenzo[b][1,4]dioxin-6-ylsulfonyl)piperazine
      References
      ReferencesAnastasiou, D., et al. 2011. Science 334, 1278.
      Boxer, M.B., et al. 2010. J. Med. Chem. 53, 1048.
      Product Information
      CAS number1186654-00-1
      FormWhite powder
      Hill FormulaC₁₈H₁₈F₂N₂O₆S₂
      Chemical formulaC₁₈H₁₈F₂N₂O₆S₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationPKM2 Activator II, DASA, is a cell-permeable, potent, and selective activator of tumor-specific M2 isozyme of pyruvate kinase (PKM2; AC50 = 65 nM).
      Biological Information
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      550602-10MG 04055977268874