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526559 PI3Kδ Inhibitor, SW30 - Calbiochem

Overview

Key Spec Table

Empirical Formula
C₂₅H₂₁N₇O₂

Pricing & Availability

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526559-5MG
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      Description
      OverviewA cell permeable, ATP-competitive and selective tolyl quinazolinone inhibitor of PI 3-Kδ (IC50 = 7 nM, 1300 nM, 85000 nM, and 740 nM for PI 3-Kδ PI 3-Kγ PI 3-Kα and PI 3-Kβ, respectively) in an enzymatic assay with an EC50 = 16 nM for PI 3-Kδ and 2.7 µM for PI 3-Kγ in a cell based assay. It elicits an inflammatory marker suppression effect in co-cultures of HUVEC and PBMCs under superantigen stimulated conditions. This compound, at concentrations between 370 nM and 10 µM, leads to a dose-dependent decrease in E-selectin expression. Furthermore, it is not cytotoxic to HUVEC cells.
      Catalogue Number526559
      Brand Family Calbiochem®
      Synonyms2-((4-amino-3-(3-hydroxyprop-1-ynyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-5-methyl-3-o-tolylquinazolin-4(3H)-one, PI 3-K Inhibitor XIV
      References
      ReferencesWilliams, O., et al. 2010. Chem Biol. 17, 123.
      Product Information
      FormWhite solid
      Hill FormulaC₂₅H₂₁N₇O₂
      Chemical formulaC₂₅H₂₁N₇O₂
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity>95% by HPLC
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Regulatory Review
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      526559-5MG 04055977270334