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521233 PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409

Primary Target: PDGFR Tyrosine Kinase
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521233
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Overview

Replacement Information

Key Spec Table

CAS #Empirical Formula
627518-40-5C₁₈H₁₆FN₃O₂

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521233-1MG
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      Description
      OverviewA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 < 33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, > 10 µM, > 10 µM, 45.8 µM and > 100 µM, respectively).
      Catalogue Number521233
      Brand Family Calbiochem®
      Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
      References
      ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
      Product Information
      CAS number627518-40-5
      ATP CompetitiveY
      FormOff-white solid
      Hill FormulaC₁₈H₁₆FN₃O₂
      Chemical formulaC₁₈H₁₆FN₃O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDGFR Tyrosine Kinase
      Primary Target IC<sub>50</sub>4.2 nM and 45 nM for -β and -α form of PDGFR, respectively
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      521233-1MG 04055977271379

      Documentation

      PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      PDGFR Tyrosine Kinase Inhibitor IV - CAS 627518-40-5 - Calbiochem Certificates of Analysis

      TitleLot Number
      521233

      References

      Reference overview
      Ho, C.Y., et al. 2005. J. Med. Chem. 48, 8163.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-August-2008 RFH
      Synonyms3-Fluoro-N-(6,7-dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamine, JNJ-10198409
      DescriptionA cell-permeable indenopyrazole compound that displays potent antiproliferative properties in several human tumor cell lines (IC50 <33 nM). Shown to act as an ATP-competitive and reversible inhibitor of PDGFR (IC50 = 4.2 nM and 45 nM for -β and -α, respectively) and c-Abl (IC50 = 22 nM). Exhibits less activity towards Lck, c-Src, and Fyn (IC50 = 100 nM, 185 nM and 378 nM, respectively) and exhibits little or no inhibition toward VEGFR, HER-2, Cdk's-1,-2,-4 &-7, bFGFR-1 and EGFR (IC50 = 3.1 µM, >10 µM, >10 µM, 45.8 µM and >100 µM, respectively).
      FormOff-white solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number627518-40-5
      Chemical formulaC₁₈H₁₆FN₃O₂
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (10 mg/ml) or Methanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful
      ReferencesHo, C.Y., et al. 2005. J. Med. Chem. 48, 8163.