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SCC197 NP69 Human Nasopharyngeal Epithelial Cell Line

The NP69 cell line is useful for studies of the mechanisms of viral-associated tumorigenesis

SCC197
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC197
      DescriptionNP69 Human Nasopharyngeal Epithelial Cell Line
      OverviewThe NP69 immortalized human nasopharyngeal epithelial cell line retains many of the characteristics of normal nasopharyngeal cells, including keratin profiles and response to TGF-beta, while possessing many of the genetic signatures observed in NPC (2). NP69 cells are non-tumorigenic and demonstrate anchorage-dependent growth (2). The NP69 cell line is particularly useful for studies of the mechanisms of viral-associated tumorigenesis.

      Source:
      NP69 cells were derived from passage 1 cultures of biopsy-isolated primary nasopharyngeal epithelial cells transfected with the PX8 plasmid containing the simian virus 40 large T antigen (1).
      Alternate Names
      • NP69SV40T
      • NP-69
      Background InformationNasopharyngeal carcinoma (NPC), the most common cancer arising in the nasopharyngeal region, arises from epithelial cells and is especially prevalent in areas of southeast Asia and as a childhood cancer in some African populations (1). NPC ontology and tumorigenesis is closely associated with viral factors, especially Epstein-Barr virus (EBV) and human papillomavirus (HPV) (1).

      References:
      1. Lancet 2016; 387(10022): 1012-1024.
      2. Biochim Biophys Acta 2002; 1590(1-3): 150-158.
      References
      Product Information
      Applications
      ApplicationThe NP69 cell line is useful for studies of the mechanisms of viral-associated tumorigenesis
      Key Applications
      • Cell Culture
      Application NotesThis product is sold solely for research use per the terms of the “Restricted Use Agreement” which govern its use as detailed in the product Data Sheet or Certificate of Analysis. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Epithelial Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X10⁶ viable cells.
      • Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are verified to be of human origin and negative for inter-species contamination from rat, mouse, chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination CLEAR panel by Charles River Animal Diagnostic Services.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells is genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • This product contains genetically modified organisms (GMO). Within the EU GMOs are regulated by Directives 2001/18/EC and 2009/41/EC of the European Parliament and of the Council and their national implementation in the member States respectively. This legislation obliges Merck to request certain information about you and the establishment where the GMOs are being handled. Click here for Enduser Declaration (EUD) Form.
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC197 04054839752827