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475944 Sigma-AldrichMyeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem

The Myeloperoxidase Inhibitor-I, also referenced under CAS 5351-17-7, controls the biological activity of Myeloperoxidase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

SDS
CoA
References
Data Sheet

Recommended Products

Overview

Replacement Information

Key Spec Table

CAS #	Empirical Formula
5351-17-7	C₇H₉N₃O

Pricing & Availability

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Description
Overview	A benzoic acid hydrazide analog that acts as a potent, irreversible, and specific inhibitor of the peroxidation activity of myeloperoxidase (MPO; IC₅₀ = 300 nM). Does not inhibit catalase or glutathione peroxidase activities. Does not affect the production of superoxide by neutrophils. Shown to inhibit H₂O₂-induced apoptosis in HL-60, human leukemia cells.
Catalogue Number	475944
Brand Family	Calbiochem®

References
References	Engelmann, I., et al. 2000. Redox Report 5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461. Burner, U., et al. 1999. J. Biol. Chem. 274, 9494. Kettle, A.J., et al. 1997. Biochem. J. 321, 503. Kettle, A.J., et al. 1995. Biochem. J. 308, 559.

Product Information
CAS number	5351-17-7
ATP Competitive	N
Form	White to beige powder
Hill Formula	C₇H₉N₃O
Chemical formula	C₇H₉N₃O
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	Myeloperoxidase
Primary Target IC<sub>50</sub>	300 nM against myeloperoxidase (MPO)
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	DG2580000

Safety Information
R Phrase	R: 36/37/38 Irritating to eyes, respiratory system and skin.
S Phrase	S: 26-36 In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. Wear suitable protective clothing.

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
Catalogue Number	GTIN
475944-1GM	04055977184266

Documentation

Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem SDS

Title
Safety Data Sheet (SDS)

Myeloperoxidase Inhibitor-I - CAS 5351-17-7 - Calbiochem Certificates of Analysis

Title	Lot Number
475944	Enter Lot Number

References

Reference overview
Engelmann, I., et al. 2000. Redox Report 5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461. Burner, U., et al. 1999. J. Biol. Chem. 274, 9494. Kettle, A.J., et al. 1997. Biochem. J. 321, 503. Kettle, A.J., et al. 1995. Biochem. J. 308, 559.

Data Sheet

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-August-2020 JSW
Description	A benzoic acid hydrazide analog that acts as a potent, specific, and irreversible inhibitor of myeloperoxidase. ABAH is a mechanism-based inhibitor that is oxidized to radical intermediates that, in turn, promote the irreversible inactivation of myeloperoxidase. Reported to inhibit hypochlorous acid (HOCl) production by purified myeloperoxidase (IC₅₀ = 300 nM). Has also been shown to inhibit HOCl production up to 90% in zymosan and phorbol myristate acetate stimulated neutrophils (IC₅₀ = 16 µM and 2.2 µM, respectively). Does not affect superoxide radical production or degranulation of neutrophils and does not inhibit catalase or glutathione peroxidase. Shown to inhibit myeloperoxidase-mediated apoptosis in >90% of ras-expressing fibroblasts and glutathione-depleted, src-transformed cells. Also shown to inhibit apoptosis in H₂O₂-treated HL-60 promyelocytic leukemia cells.
Form	White to beige powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	5351-17-7
RTECS	DG2580000
Chemical formula	C₇H₉N₃O
Structure formula
Purity	≥95% by HPLC
Solubility	DMSO (10 mg/ml) and dilute acids
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Irritant
References	Engelmann, I., et al. 2000. Redox Report 5, 207. Wagner, B.A., et al. 2000. J. Biol. Chem. 275, 22461. Burner, U., et al. 1999. J. Biol. Chem. 274, 9494. Kettle, A.J., et al. 1997. Biochem. J. 321, 503. Kettle, A.J., et al. 1995. Biochem. J. 308, 559.

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