Millipore Sigma Vibrant Logo

104354 L-Histidine monohydrochloride monohydrate

EMPROVE® EXPERT Ph Eur,BP,ChP,JP

L-Histidine monohydrochloride monohydrate MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: His

CAS #: 5934-29-2 EC Number: 211-438-9 Molar Mass: 209.63 g/mol Hill Formula: C₆H₁₀ClN₃O₂ * H₂O Grade: Ph Eur,BP,ChP,JP
View Products on Sigmaaldrich.com
104354
View Pricing & Availability
Learn about the Emprove® Program

Overview

Replacement Information

Key Spec Table

CAS #EC NumberHill FormulaMolar MassGrade Value
5934-29-2211-438-9C₆H₁₀ClN₃O₂ * H₂O209.63 g/molPh Eur,BP,ChP,JP

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
1043540001
Retrieving availability...
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      		 Plastic bottle 3 x 500 g
      Retrieving price...
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      —
      Request Pricing
      		 —
      1043540500
      Retrieving availability...
      —
      Fulfillment and delivery delayed Fulfillment and delivery delayed
      In Stock 
      Discontinued
      Limited Quantities Available
      Availability to be confirmed
        Remaining : Will advise
          Remaining : Will advise
          Will advise
          Contact Customer Service
          Contact Customer Service

          		 Plastic bottle 500 g
          Retrieving price...
          Price could not be retrieved
          Minimum Quantity is a multiple of
          Maximum Quantity is
          Upon Order Completion More Information
          You Saved ()
           
          —
          Request Pricing
          		 —
          1043549010
          Retrieving availability...
          —
          Fulfillment and delivery delayed Fulfillment and delivery delayed
          In Stock 
          Discontinued
          Limited Quantities Available
          Availability to be confirmed
            Remaining : Will advise
              Remaining : Will advise
              Will advise
              Contact Customer Service
              Contact Customer Service

              		 Plastic drum 10 kg
              Retrieving price...
              Price could not be retrieved
              Minimum Quantity is a multiple of
              Maximum Quantity is
              Upon Order Completion More Information
              You Saved ()
               
              —
              Request Pricing
              		 —
              Description
              Catalogue Number104354
              SynonymsHis
              References
              Product Information
              CAS number5934-29-2
              EC number211-438-9
              GradePh Eur,BP,ChP,JP
              Hill FormulaC₆H₁₀ClN₃O₂ * H₂O
              Molar Mass209.63 g/mol
              HS Code2933 29 92
              Structure formula ImageStructure formula Image
              Quality LevelMQ500
              Applications
              Biological Information
              Physicochemical Information
              Density1.4723 g/cm3 (20 °C)
              Melting Point256 - 268 °C (decomposition)
              pH value4.38 - 4.48 (149.55 g/l, H₂O, 20 °C)
              Vapor pressure<0.1 hPa (20 °C)
              Bulk density770 kg/m3
              Solubility149.55 g/l
              Dimensions
              Materials Information
              Toxicological Information
              Safety Information according to GHS
              RTECSMS3119000
              Storage class10 - 13 Other liquids and solids
              WGKWGK 1 slightly hazardous to water
              Disposal3
              Relatively unreactive organic reagents should be collected in container A. If halogenated, they should be collected in container B. For solid residues use container C.
              Safety Information
              Product Usage Statements
              Storage and Shipping Information
              StorageStore at +2°C to +30°C.
              Packaging Information
              Transport Information
              Supplemental Information
              Specifications
              Assay (calculated on dried substance)99.0 - 101.0 %
              Assay (calc.on anhydrous substance)99.0 - 101.0 %
              Identity (IR-spectrum)passes test
              Identity (pH)passes test
              Identity (wet chemistry)passes test
              Identity (specific rotation)passes test
              Identity (TLC)passes test
              Appearancewhite to almost white crystalline powder or colorless crystals
              Appearance of solution (50 g/l CO₂-free water)clear and not more intense in color than reference solution BY₆
              Appearance of solution (100 g/l, CO₂-free water)clear and colorless
              Transmittance of solution (100 g/l, water)≥ 98.0 %
              pH (50 g/l CO₂-free water)3.0 - 5.0
              pH (100 g/l, CO₂-free water)3.5 - 4.5
              Acidity (100 g/l, water)3.5 - 4.5
              Spec. rotation (α 20/D, 110 g/l, hydrochloric acid 120 g/l, calc. on dried substance)+9.2 to +10.6
              Spec. rotation (α 20/D, 110 g/l, hydrochloric acid 6 mol/l, calc. on dried substance)+8.5 to +10.5
              Spec. rotation (α 20/D, 110 g/l, hydrochloric acid 6 mol/l, calc. on anhydrous substance)+9.2 to +10.6
              Chloride (argentometric, calc. on dried substance)16.7 - 17.1 %
              Sulfate (SO₄)≤ 200 ppm
              Heavy metals (as Pb)≤ 10 ppm
              As (Arsenic)≤ 1 ppm
              Fe (Iron)≤ 10 ppm
              Other amino acids (TLC)≤ 0.2 %
              Related substances (TLC)passes test
              Ninhydrin-positive substances (LC) (any ninhydrin-positive impurity)≤ 0.2 %
              Ninhydrin-positive substances (LC) (ammonium (570 nm))≤ 0.02 %
              Ninhydrin-positive substances (LC) (total impurities)≤ 0.5 %
              Residual solvents (ICH (Q3C))excluded by manufacturing process
              Sulfated ash (600 °C)≤ 0.1 %
              Loss on drying (150 °C)7.0 - 10.0 %
              Loss on drying (105 °C; 3 h)≤ 0.2 %
              Water (according to Karl Fischer)7.2 - 10.0 %
              Bacterial endotoxins≤ 20 I.U./g
              Bacterial endotoxins (ChP)< 6.0
              Microbiological test (total aerobic microbial count (TAMC))≤ 10²
              Microbiological test (total yeast and mould count (TYMC))≤ 10¹
              Elemental impurity specifications have been set considering ICH Q3D (Guideline for Elemental Impurities). Class 1-3 elements are not likely to be present above the ICH Q3D option 1 limit, unless specified and indicated (*).
              Corresponds to Ph. Eur., BP, ChP, JP
              Global Trade Item Number
              Catalogue Number GTIN
              1043540001 04027269368289
              1043540500 04022536050348
              1043549010 04022536732657

              Documentation

              Material Qualification Dossier

              TitleVersion
              9.0

              Quality Management Dossier (Open Access)

              Title

              Operational Excellence Dossier

              Title

              L-Histidine monohydrochloride monohydrate SDS

              Title

              Safety Data Sheet (SDS) 

              L-Histidine monohydrochloride monohydrate Certificates of Analysis

              Product Number PackagingSpecificationLot Number
              1043540001 Plastic bottlePDF Specification Document
              1043540500 Plastic bottlePDF Specification Document
              1043549010 Plastic drumPDF Specification Document

              Certificates

              Title

              Related Products & Applications

              Related Products By: Brand Facete

              EMPROVE®

              Categories

              Biopharmaceutical Manufacturing > Formulation > Liquid Dosage > Ingredients - Liquid
              Small Molecule Pharmaceuticals > Formulation > Liquid Dosage Form > Ingredients - Liquid
              Biopharmaceutical Manufacturing > Upstream Processing > Cell Culture > Cell Culture Ingredients and Supplements > Cell Culture Ingredients > Amino Acids
              Biopharmaceutical Manufacturing > Formulation > Liquid Dosage > pH Adjustments and Isotonizers
              Biopharmaceutical Manufacturing > Formulation > Liquid Dosage > Surfactants and Stabilizers
              Small Molecule Pharmaceuticals > Formulation > Liquid Dosage Form > pH Adjustments and Isotonizers
              Small Molecule Pharmaceuticals > Formulation > Liquid Dosage Form > Surfactants and Stabilizers