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557404 InSolution™ RNA Polymerase III Inhibitor - CAS 577784-91-9 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
577784-91-9C₁₉H₁₅Cl₂N₃O₂S₂

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
557404-5MG
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      Glass bottle 5 mg
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      Description
      OverviewA cell-permeable inhibitor of RNA polymerase III (RNA Pol III) (IC50 = 27 µM for human RNA Pol III and 32 µM for Saccharomyces cerevisiae RNA Pol III). Inhibits cell growth in yeast by preventing RNA Pol III-mediated tRNA transcription. The solid form of this compound (Cat. No. 557403) is also available.
      Catalogue Number557404
      Brand Family Calbiochem®
      Synonyms2-Chloro-N-(3-(5-chloro-3-methylbenzo[b]thiophen-2-yl)-1-methyl-1H-pyrazol-5-yl)benzenesulfonamide, N-(1-(3-(5-Chloro-3-methylbenzo[b]thiophen-2-yl-1-methyl-1H-pyrazol-5-yl))-2-chlorobenzenesulfonamide
      References
      ReferencesWu, L., et al. 2003. Euk. Cell 2, 256.
      Product Information
      CAS number577784-91-9
      FormLiquid
      FormulationA 25 mM (5 mg/442 µL) solution of RNA Polymerase III Inhibitor (Cat. No. 557403) in DMSO.
      Hill FormulaC₁₉H₁₅Cl₂N₃O₂S₂
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetRNA Polymerase III
      Primary Target IC<sub>50</sub>27 µ
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information
      R PhraseR: 36/38

      Irritating to eyes and skin.
      S PhraseS: 26-36

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C). Aliquots are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      557404-5MG 04055977268065