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EZHPI-15BK Human Total Proinsulin ELISA- Space Saver (Bulk) Packaging

This Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.

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EZHPI-15BK
Ten 96-well strip plates.  This product contains 10 Total Proinsulin ELISA kits.
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      Overview

      Replacement Information
      Description
      Catalogue NumberEZHPI-15BK
      DescriptionHuman Total Proinsulin ELISA- Space Saver (Bulk) Packaging
      Background InformationProinsulin, the precursor of insulin and C-peptide, is made by the beta cells of the pancreas. This kit measures the intact and intermediate metabolic forms of human proinsulin.
      References
      Product Information
      Detection methodFluorescent Colorimetric
      Precision, %
      • Inter-assay: 2.9–8.3
      • Intra-assay: 0.8–8.5
      Quality LevelMQ200
      Applications
      ApplicationThis Human Total Proinsulin ELISA is used to measure & quantify Proinsulin levels in Metabolism & Endocrine & Cell Signaling research.
      Key Applications
      • ELISA
      Application Notes20 μL sample volume 3 hour assay, room temperature
      Biological Information
      Species Reactivity
      • Human
      Analytes Available
      • Proinsulin
      Entrez Gene Number
      Entrez Gene SummaryAfter removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region.
      Gene Symbol
      • INS
      • proinsulin
      • insulin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01308 # Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.
      SIZE: 110 amino acids; 11981 Da
      SUBUNIT: Heterodimer of a B chain and an A chain linked by two disulfide bonds.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P01308 # Defects in INS are the cause of familial hyperproinsulinemia [MIM:176730].
      SIMILARITY: SwissProt: P01308 ## Belongs to the insulin family.
      Accuracy
      • 88–103%
      Physicochemical Information
      Sensitivity
      • 0.5 pM
      Linearity of Dilution84–120%
      Standard Curve Range
      • 2–200 pM
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • For research use only. Not for use in diagnostic procedures.
      Storage and Shipping Information
      Packaging Information
      Material SizeTen 96-well strip plates.
      Material PackageThis product contains 10 Total Proinsulin ELISA kits.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      EZHPI-15BK 04053252436994

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