Millipore Sigma Vibrant Logo

373270 Hec1/Nek2 Mitotic Pathway Inhibitor I, INH1 - CAS 313553-47-8 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
313553-47-8C₁₈H₁₆N₂OS

Pricing & Availability

Catalogue Number AvailabilityPackaging Qty/Pack Price Quantity
373270-10MG
Fulfillment and delivery delayed
Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      10 mg
      Price could not be retrieved
      Minimum Quantity is a multiple of
      Maximum Quantity is
      Upon Order Completion More Information
      You Saved ()
       
      Request Pricing
      Description
      OverviewA cell-permeable thiazolyl benzamide compound that directly binds Hec1 and disrupts Hec1/Nek2 complex formation, resulting in defective Hec1 kinetochores localization and cellular Nek2 destabilization/downregulation. Shown to induce a transient mitotic arrest in HeLa cultures and inhibit the proliferation of 10 breast cancer cell lines (GI50 of 10-21 µM) as well as the cervical HeLa and colon HCT116 cancer lines, while exhibiting reduced potency against the noncancerous MCF10A line (GI50 = 41 µM). Reported to suppress the MDA-MB-468-derived tumor growth (by ~53% and ~75% 3 wks after a 7-wk treatment period with 50 mg/kg and 100 mg/kg INH1, repectively, i.p.) in a murine breast cancer model in vivo.
      Catalogue Number373270
      Brand Family Calbiochem®
      SynonymsN-(4-(2,4-Dimethylphenyl)-thiazol-2-yl)-benzamide, INH1, Inhibitor of Nek2/Hec1-1
      References
      ReferencesWu, G., et al. 2008. Cancer Res. 68, 8393.
      Product Information
      CAS number313553-47-8
      FormWhite solid
      Hill FormulaC₁₈H₁₆N₂OS
      Chemical formulaC₁₈H₁₆N₂OS
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Purity≥97% by HPLC
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      373270-10MG 04055977191011