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345700 Ganciclovir - CAS 82410-32-0 - Calbiochem

Overview

Key Spec Table

CAS #Empirical Formula
82410-32-0C₉H₁₃N₅O₄

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345700-50MG
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      Glass bottle 50 mg
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      Description
      OverviewA nucleoside analog structurally related to Acyclovir (Cat. No. 114798). Acts as a prodrug that is activated by phosphorylation. Has been used in the study of “suicide” gene therapy in cancer research. Upon expression of a viral suicide gene encoding herpes simplex virus, thymidine kinase (TK), the non-toxic prodrug ganciclovir, is converted to an active phosphorylated analog that can be incorporated into the DNA of replicating eukaryotic cells, causing death of the malignant dividing cell. Causes an irreversible cell cycle arrest at the G2/M checkpoint. Has also been used to study the loss of telomeres and to evaluate sensitivity of viruses to antiviral agents.
      Catalogue Number345700
      Brand Family Calbiochem®
      Synonyms9-[(1,3-Dihydroxy-2-propoxy)methyl]guanine
      References
      ReferencesAghi, M., et al. 2000. J. Gene Med. 2, 148.
      Qiao, J., et al. 2000. Hum. Gene Ther. 11, 1569.
      Cannon, J.S., et al. 1999. J. Virol. 73, 4786.
      Rubsam, L.Z., et al. 1999. Cancer Res. 59, 669.
      Sprung, C.N., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 6781.
      Yamasaki, H., et al. 1999. C.R. Acad. Sci. III 322, 151.
      Halloran, P.J., and Fenton, R.G. 1998. Cancer Res. 58, 3855.
      Product Information
      CAS number82410-32-0
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₉H₁₃N₅O₄
      Chemical formulaC₉H₁₃N₅O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      ApplicationGanciclovir, CAS 82410-32-0, is a nucleoside analog related to Acyclovir. Acts as a prodrug that is activated by phosphorylation. Inhibits the replication of cytomegalovirus (CMV; IC50 = 10 nM).
      Biological Information
      Primary TargetActs as a prodrug that is activated by phosphorylation
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Safety Information according to GHS
      RTECSMF8407000
      Safety Information
      R PhraseR: 46-60-61

      May cause heritable genetic damage.
      May impair fertility.
      May cause harm to the unborn child.
      S PhraseS: 36/37/39-45-53

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Avoid exposure - obtain special instructions before use.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Catalogue Number GTIN
      345700-50MG 04055977194500