361556 Sigma-AldrichGSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem
The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.
More>> The GSK-3 Inhibitor IX, Control, MeBIO, also referenced under CAS 710323-61-8, controls the biological activity of GSK-3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: 1-Methyl-BIO
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Overview
| Replacement Information |
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Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 710323-61-8 | C₁₇H₁₂BrN₃O₂ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 361556-1MG |
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Plastic ampoule | 1 mg |
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| Description | |
|---|---|
| Overview | A cell-permeable N-methylated analog of GSK-3 Inhibitor IX, BIO (Cat. No. 361550) that serves as a relevant kinase inactive control (IC50 > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β). Acts as a potent ligand for aryl hydrocarbon receptor (AhR; EC50 = 20 nM and 93 nM for yeast and hepatoma reporter systems, respectively) and displays antiproliferative properties. |
| Catalogue Number | 361556 |
| Brand Family | Calbiochem® |
| Synonyms | 1-Methyl-BIO |
| References | |
|---|---|
| References | Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |
| Product Information | |
|---|---|
| CAS number | 710323-61-8 |
| ATP Competitive | N |
| Form | Dark red solid |
| Hill Formula | C₁₇H₁₂BrN₃O₂ |
| Chemical formula | C₁₇H₁₂BrN₃O₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Applications |
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| Biological Information | |
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| Primary Target | Relevant kinase inactive control |
| Primary Target IC<sub>50</sub> | > 92 µM for Cdk1/B, > 100 µM for Cdk5/p25, and GSK-3α/β |
| Purity | ≥97% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS |
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| Safety Information |
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| Product Usage Statements |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
| Transport Information |
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| Supplemental Information |
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| Specifications |
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| Global Trade Item Number | |
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| Catalogue Number | GTIN |
| 361556-1MG | 04055977214161 |
Documentation
GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem SDS
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GSK-3 Inhibitor IX, Control, MeBIO - CAS 710323-61-8 - Calbiochem Certificates of Analysis
| Title | Lot Number |
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| 361556 |
References
| Reference overview |
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| Knockaert, M., et al. 2004. Oncogene 23, 4400. Polychronopoulos, P., et al. 2004. J. Med. Chem. 47, 935. Meijer, L., et al. 2003. Chem. Biol. 10, 1255. |