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309866 Diltiazem, Hydrochloride - CAS 33286-22-5 - Calbiochem

Synthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: L-Type Calcium Channel Blocker II

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309866
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Overview

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309866-100MG
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      Description
      OverviewSynthetic benzothiazepine that acts as an L-type Ca2+ channel antagonist. Similar in function to Nifedipine (Cat. No. 481981) and Verapamil (Cat. No. 676777). Has negative inotropic effects on the heart. Strongly suppresses conductance at the A-V node and automaticity at the S-A node. Has also been shown to regulate Ca2+ release from intracellular stores in neutrophils.
      Catalogue Number309866
      Brand Family Calbiochem®
      SynonymsL-Type Calcium Channel Blocker II
      References
      Referencesvan Zwieten, P.A., and Pfaffendorf, M. 1993. J. Hypertens. Suppl. 11, S3.
      Rosales, C., and Brown, E.J. 1992. J. Biol. Chem. 267, 1443.
      Julian, D.G. 1987. Am. J. Cardiol. 59, 37J.
      Campbell, K.P., et al. 1986. Proc. Natl. Acad. Sci. USA 83, 2792.
      Gallizzi, J.P., et al. 1986. J. Biol. Chem. 261, 1393.
      Garcia, M.L., et al. 1986. J. Biol. Chem. 261, 8146.
      Product Information
      CAS number33286-22-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₂H₂₆N₂O₄S · HCl
      Chemical formulaC₂₂H₂₆N₂O₄S · HCl
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetL-type Ca2+ channel
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSDL0310000
      Safety Information
      R PhraseR: 22-40

      Harmful if swallowed.
      Limited evidence of a carcinogenic effect.
      S PhraseS: 36

      Wear suitable protective clothing.
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +15°C to +30°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 2 weeks at 4°C.
      Global Trade Item Number
      Catalogue Number GTIN
      309866-100MG 04055977216820