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14-520 Casein Kinase 1δ (aa 1-294) Protein, active, 10 µg

Active, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.

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14-520
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.
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      Overview

      Description
      Catalogue Number14-520
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionCasein Kinase 1δ (aa 1-294) Protein, active, 10 µg
      OverviewN-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationActive, N-terminal, GST-tagged, recombinant human CK1 delta, amino acids 1-294, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the casein kinase I (CKI) gene family whose members have been implicated in the control of cytoplasmic and nuclear processes, including DNA replication and repair. The encoded protein is highly similar to the mouse and rat CK1 delta homologs. Two transcript variants encoding different isoforms have been found for this gene.
      Gene Symbol
      • CSNK1D
      • CKI-delta
      • HCKID
      • CKId
      Protein TargetCK1γδ
      Purification MethodGlutathione-agarose
      Target Sub-FamilyCK1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P48730 # Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating PER1 and PER2. Retains PER1 in the cytoplasm.
      SIZE: 415 amino acids; 47330 Da
      SUBUNIT: Monomer. Component of the circadian core oscillator, which includes the CRY proteins, CLOCK, or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS and the PER proteins. Interacts directly with PER1 and PER2 which may lead to their degradation.
      SUBCELLULAR LOCATION: Cytoplasm.
      TISSUE SPECIFICITY: Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. In blood, highly expressed in hemopioetic cells and mature granulocytes. Also found in monocytes and lymphocytes.
      PTM: Autophosphorylated on serine and threonine residues (By similarity).
      DISEASE: "SwissProt: P48730 # Defects in CSNK1D are a cause of familial advanced sleep- phase syndrome (FASPS) [MIM:604348]. FASPS is characterized by very early sleep onset and offset. Individuals are 'morning larks' with a 4 hours advance of the sleep, temperature and melatonin rhythms."
      SIMILARITY: SwissProt: P48730 ## Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. & Contains 1 protein kinase domain.
      Molecular Weight61kDa
      Product Usage Statements
      Quality Assuranceroutinely evaluated by phosphorylation of KRRRALS(p)VASLPGL
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditions6 months at -20°C
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-520M when ordering the 250 µg size.
      Global Trade Item Number
      Catalogue Number GTIN
      14-520 04053252401565