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ALP60-100UG Apolipoprotein C-III, human

Apolipoprotein C-III, human MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Key Applications: Positive Control UniProt Number: P02656 Entrez Gene Number: NM_000040.1
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ALP60-100UG
100 µg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberALP60-100UG
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionApolipoprotein C-III, human
      OverviewMOLECULAR WEIGHT:

      8,750
      Alternate Names
      • ApoCIII
      Background InformationThe physiological role of Apo CIII is unknown. It is suggested that Apo CIII may inhibit the activation of lipoprotein lipase by Apo CII.
      References
      Product Information
      HS Code3002 12 29
      PresentationLiquid in 10 mM NH4HCO3, pH 7.4.
      Quality LevelMQ100
      Applications
      Key Applications
      • Positive Control
      Biological Information
      Purity> 95% by SDS-PAGE
      SourceHuman plasma tested negative for HBsAg and HIV-I, HIV-II, HBc and Hepatitis C antibodies. All blood products should be treated as potentially infectious.
      Entrez Gene Number
      Entrez Gene SummaryApolipoprotein C-III is a very low density lipoprotein (VLDL) protein. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to delay catabolism of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia.
      Gene Symbol
      • APOC3
      • ApoC-III
      • Apo-CIII
      • APOCIII
      • MGC150353
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P02656 # Inhibits lipoprotein lipase and hepatic lipase and decreases the uptake of lymph chylomicrons by hepatic cells. This suggests that it delays the catabolism of triglyceride-rich particles.
      SIZE: 99 amino acids; 10852 Da
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Constitutes 50% of the protein fraction of VLDL and 2% of that of HDL. Synthesized predominantly in liver and to a lesser degree in intestine.
      PTM: O-linked glycan consists of Gal-GalNAc disaccharide, further modified with up to 3 sialic acid residues.
      DISEASE:SwissProt: P02656 # Defects in APOC3 may be a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL).
      SIMILARITY: SwissProt: P02656 ## Belongs to the apolipoprotein C3 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20ºC or below in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles. All blood products should be treated as potentially infectious.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ALP60-100UG 04053252286988

      Documentation

      Apolipoprotein C-III, human SDS

      Title

      Safety Data Sheet (SDS) 

      Apolipoprotein C-III, human Certificates of Analysis

      TitleLot Number
      HUMAN APOLIPOPROTEIN C-III PURIFIED - 2141798 2141798
      HUMAN APOLIPOPROTEIN C-III PURIFIED - 2382595 2382595
      HUMAN APOLIPOPROTEIN C-III PURIFIED - 2424091 2424091
      HUMAN APOLIPOPROTEIN C-III PURIFIED - 2436308 2436308
      HUMAN APOLIPOPROTEIN C-III - 3153325 3153325
      HUMAN APOLIPOPROTEIN C-III - 3816386 3816386
      HUMAN APOLIPOPROTEIN C-III - 3954397 3954397
      HUMAN APOLIPOPROTEIN C-III - 4048663 4048663
      HUMAN APOLIPOPROTEIN C-III - 4174756 4174756
      HUMAN APOLIPOPROTEIN C-III - 4197642 4197642
      Show more

      Data Sheet

      Title
      HUMAN APOLIPOPROTEIN C-III PURIFIED

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