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07-211 Anti-phospho-Met (Tyr1234/1235) Antibody

Detect phospho-Met (Tyr1234/1235) using this Anti-phospho-Met (Tyr1234/1235) Antibody validated for use in WB.

Anti-phospho-Met (Tyr1234/1235) Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: MET, AUTS9, c-Met, RCCP2, HGFR UniProt Number: P08581
07-211
200 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-211
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-Met (Tyr1234/1235) Antibody
      Alternate Names
      • c-Met
      • cmet
      • HGFR
      • RCCP2
      • met proto-oncogene (hepatocyte growth factor receptor)
      References
      Product Information
      FormatAffinity Purified
      Control
      • NIH-3T3 cells co-expressing MET/HGFR and HGF
      PresentationImmunoaffinity Purified immunoglobulin in 0.2M Tris-glycine, pH 7.4, 0.15M NaCl, 0.1mM EDTA, 0.05% sodium azide before the addition of glycerol to 30%.
      Applications
      ApplicationDetect phospho-Met (Tyr1234/1235) using this Anti-phospho-Met (Tyr1234/1235) Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      Immunogenpeptide (DKE[pY][pY]SVHNK-C) corresponding to amino acids 1231-1240 of human phospho-Met/HGFR
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes phosphorylated Met.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe proto-oncogene MET product is the hepatocyte growth factor receptor and encodes tyrosine-kinase activity. The primary single chain precursor protein is post-translationally cleaved to produce the alpha and beta subunits, which are disulfide linked to form the mature receptor. Various mutations in the MET gene are associated with papillary renal carcinoma.
      Gene Symbol
      • MET
      • AUTS9
      • c-Met
      • RCCP2
      • HGFR
      Modifications
      • Phosphorylation
      Purification MethodImmunoAffinity Purified
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P08581 # Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity.
      SIZE: 1390 amino acids; 155527 Da
      SUBUNIT: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10.
      SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.
      DISEASE: SwissProt: P08581 # Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. & Defects in MET may be associated with gastric cancer. & Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]. & Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. & Genetic variations in MET may be associated with susceptibility to autism type 1B (AUTS1B) [MIM:608636]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior.
      SIMILARITY: SwissProt: P08581 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. & Contains 3 IPT/TIG domains. & Contains 1 protein kinase domain. & Contains 1 Sema domain.
      Molecular Weight140 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from NIH-3T3 cells co-expressing MET/HGFR and HGF
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      07-211 04053252728747

      Documentation

      Anti-phospho-Met (Tyr1234/1235) Antibody Certificates of Analysis

      TitleLot Number
      Anti-phospho-Met (Tyr1234/1235) - 20438 20438
      Anti-phospho-Met (Tyr1234/1235) - 21837 21837
      Anti-phospho-Met (Tyr1234/1235) - 23486 23486
      Anti-phospho-Met (Tyr1234/1235) - 23746 23746
      Anti-phospho-Met (Tyr1234/1235) - 25335 25335
      Anti-phospho-Met (Tyr1234/1235) - 30022 30022

      References

      Reference overviewApplicationPub Med ID
      In vitro differentiation of human adipose tissue-derived stem cells into cells with pancreatic phenotype by regenerating pancreas extract.
      Jiyeon Lee,Duck-Jong Han,Song-Cheol Kim
      Biochemical and biophysical research communications  375  2008

      Show Abstract       		18725201 18725201
      Synergistic effect of focal adhesion kinase overexpression and hepatocyte growth factor stimulation on cell transformation
      Chan, P. C., et al
      J Biol Chem, 277:50373-9 (2002)  2002

      		Immunoblotting (Western)12393896 12393896

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies