Millipore Sigma Vibrant Logo

AB5404 Anti-Neurturin Antibody

View Products on Sigmaaldrich.com
AB5404
50 µL  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Fulfillment and delivery delayed
Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RIHCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB5404
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Neurturin Antibody
      References
      Product Information
      FormatSerum
      PresentationRabbit serum. Lyophilized. Contains no preservative. Reconstitute with 50 μL of sterile distilled water. Centrifuge if necessary to remove any residue.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Neurturin Antibody detects level of Neurturin & has been published & validated for use in IH.
      Key Applications
      • Immunohistochemistry
      Application NotesImmunohistochemistry: 1:1,000-1:2,000

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant human Neurturin.
      HostRabbit
      SpecificityNeurturin. No cross reactivity with GDNF.
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryNeurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease.
      Gene Symbol
      • NRTN
      • NTN
      • neurturin
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q99748 # Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
      SIZE: 197 amino acids; 22405 Da
      SUBUNIT: Homodimer; disulfide-linked.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE: SwissProt: Q99748 # Defects in NRTN are a cause of Hirschsprung disease (HSCR) [MIM:142623]. In association with mutations of RET gene, and possibly with other loci, defects in NRTN are involved in Hirschsprung disease. This genetic disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
      SIMILARITY: SwissProt: Q99748 ## Belongs to the TGF-beta family. GDNF subfamily.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain lyophilized material at -20°C to -70°C for up to 6 months. After reconstitution maintain frozen at -20°C in undiluted aliquots for up to 6 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB5404 04053252272585

      Documentation

      Anti-Neurturin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Neurturin Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-NEURTURIN - 3195398 3195398
      RABBIT ANTI-NEURTURIN - 3255323 3255323
      RABBIT ANTI-NEURTURIN - 3587185 3587185
      RABBIT ANTI-NEURTURIN - 3693096 3693096
      RABBIT ANTI-NEURTURIN -2681164 2681164
      RABBIT ANTI-NEURTURIN -2887225 2887225
      RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY 2485723
      RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY 3083068
      RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY - 2053346 2053346
      RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY - 2537447 2537447

      References

      Reference overviewApplicationSpeciesPub Med ID
      Long-term preservation of cone photoreceptors and visual acuity in rd10 mutant mice exposed to continuous environmental enrichment.
      Barone, I; Novelli, E; Strettoi, E
      Molecular vision  20  1545-56  2014

      Show Abstract
      ImmunohistochemistryMouse25489227 25489227
      Environmental enrichment extends photoreceptor survival and visual function in a mouse model of retinitis pigmentosa.
      Barone, I; Novelli, E; Piano, I; Gargini, C; Strettoi, E
      PloS one  7  e50726  2012

      Show Abstract
      23209820 23209820
      Neurturin, a relative of glial-cell-derived neurotrophic factor
      Kotzbauer, P. et al.
      Nature, 384:467-470 (1996)  1996

      8945474 8945474

      Data Sheet

      Title
      RABBIT ANTI-NEURTURIN POLYCLONAL ANTIBODY