Millipore Sigma Vibrant Logo

AB1526 Anti-Nerve Growth Factor-β Antibody

View Products on Sigmaaldrich.com
AB1526
250 µL  
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
Request Pricing
Fulfillment and delivery delayed
Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      Ch, H, M, RELISA, WB, IHC, FUNCRbSerumPolyclonal Antibody
      Description
      Catalogue NumberAB1526
      Replaces04-1119
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Nerve Growth Factor-β Antibody
      Alternate Names
      • NGFbeta
      Product Information
      FormatSerum
      PresentationWhole rabbit antisera. Lyophilized. Reconstitute with 250 μL of sterile distilled water.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Nerve Growth Factor-β Antibody is validated for use in ELISA, WB, IH, FUNC for the detection of Nerve Growth Factor-β.
      Key Applications
      • ELISA
      • Western Blotting
      • Immunohistochemistry
      • Affects Function
      Application NotesImmunohistochemistry at 1:500-1:5,000 (see suggested protocol).

      Immunoblotting at 1:500-1:5,000.

      ELISA at 1:500-1:5,000.

      Inhibition of biological activity in vitro at 1:10-1:50.
      BIOLOGICAL ACTIVITY: This antibody will completely inhibit the survival and neurite outgrowth actions of mouse NGF in chicken dorsal root ganglion neurons in vitro.

      Use neat for in vivo animal studies.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenMouse nerve growth factor-beta purified from salivary glands.
      HostRabbit
      SpecificityNerve growth factor-beta (NGF). Less than 1% cross-reactivity against recombinant human NT3, NT4 and BDNF by ELISA.
      Species Reactivity
      • Chicken
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene is a member of the NGF-beta family and encodes a secreted protein which homodimerizes and is incorporated into a larger complex. This protein has nerve growth stimulating activity and the complex is involved in the regulation of growth and the differentiation of sympathetic and certain sensory neurons. Mutations in this gene have been associated with hereditary sensory and autonomic neuropathy, type 5 (HSAN5), and dysregulation of this gene's expression is associated with allergic rhinitis.
      Gene Symbol
      • NGFB
      • HSAN5
      • NGF
      • Beta-NGF
      • MGC161426
      • MGC161428
      Non-Reactive Species
      • Bovine
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01138 # Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. It stimulates division and differentiation of sympathetic and embryonic sensory neurons.
      SIZE: 241 amino acids; 26959 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE: SwissProt: P01138 # Defects in NGFB are the cause of hereditary sensory and autonomic neuropathy type 5 (HSAN5) [MIM:608654]. Hereditary sensory and autonomic neuropathies are characterized by loss of pain sensation in combination with other sensory and/or autonomic abnormalities. HSAN5 patients manifest loss of pain perception and impaired temperature sensitivity, ulcers, and in some cases self- mutilation. The autonomic involvement is variable.
      SIMILARITY: SwissProt: P01138 ## Belongs to the NGF-beta family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C to -70°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size250 µL
      Global Trade Item Number
      Catalogue Number GTIN
      AB1526 04053252514654