Millipore Sigma Vibrant Logo

AB9450 Anti-Metabotropic Glutamate Receptor 6 Antibody

This Anti-Metabotropic Glutamate Receptor 6 Antibody is validated for use in IH(P) for the detection of Metabotropic Glutamate Receptor 6.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRM6, DKFZp686H1993, GPRC1F, mGluR6, MGLUR6, CSNB1B, mGlu6 UniProt Number: O15303
View Products on Sigmaaldrich.com
AB9450
50 µg  
Retrieving price...
Price could not be retrieved
Minimum Quantity is a multiple of
Maximum Quantity is
Upon Order Completion More Information
You Saved ()
 
—
Request Pricing
—
Fulfillment and delivery delayed Fulfillment and delivery delayed
In Stock 
Discontinued
Limited Quantities Available
Availability to be confirmed
    Remaining : Will advise
      Remaining : Will advise
      Will advise
      Contact Customer Service
      Contact Customer Service

      Special Offers

       

      Contact Customer Service

      Overview

      Replacement Information

      Special Offers

      100% Performance Guaranteed

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)RbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9450
      ReplacesAB5826
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Metabotropic Glutamate Receptor 6 Antibody
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS, pH 7.7 with less than 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Metabotropic Glutamate Receptor 6 Antibody is validated for use in IH(P) for the detection of Metabotropic Glutamate Receptor 6.
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on formalin-fixed, paraffin-embedded tissue sections.

      Western Blot

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminal extracellular domain of human Metabotropic Glutamate Receptor 6.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Metabotropic Glutamate Receptor 6 [mGluR6].
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
      Gene Symbol
      • GRM6
      • DKFZp686H1993
      • GPRC1F
      • mGluR6
      • MGLUR6
      • CSNB1B
      • mGlu6
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O15303 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity.
      SIZE: 877 amino acids; 95437 Da
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      DISEASE: SwissProt: O15303 # Defects in GRM6 are the cause of congenital stationary night blindness type 1B (CSNB1B) [MIM:257270]. This disorder consits of a previously unrecognized, autosomal recessive form of congenital night blindness associated with a negative electroretinogram waveform. Patients are night blind from an early age, and when maximally dark-adapted, they could perceive lights only with an intensity equal to or slightly dimmer than that normally detected by the cone system. ERGs in response to single brief flashes of light have clearly detectable a-waves, which are derived from photoreceptors, and greatly reduced b-waves, which are derived from the second-order inner retinal neurons. ERGs in response to sawtooth flickering light indicate a markedly reduced ON response and a nearly normal OFF response. There is no subjective delay in the perception of suddenly appearing white vs black objects on a gray background.
      SIMILARITY: SwissProt: O15303 ## Belongs to the G-protein coupled receptor 3 family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB9450 04053252583018