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ABN643 Anti-LRRTM2 Antibody

Anti-LRRTM2 Antibody detects level of LRRTM2 & has been published & validated for use in LRRTM2.

Anti-LRRTM2 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Developmental Neuroscience Gene Symbol: LRRTM2, KIAA0416, LRRN2 UniProt Number: O43300
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ABN643
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN643
      DescriptionAnti-LRRTM2 Antibody
      Alternate Names
      • Leucine-rich repeat transmembrane neuronal protein 2
      • Leucine-rich repeat neuronal 2 protein
      • LRRTM2
      Background InformationLeucine-rich repeat transmembrane neuronal protein 2, also known as Leucine-rich repeat neuronal 2 protein, and encoded by the gene name LRRTM2 or LRRN2, is involved in the development and maintenance of excitatory synapse in the vertebrate nervous system. The Leucine-rich repeat transmembrane neuronal proteins (LRRTMs) are differentially expressed in the nervous system and were recently found to instruct presynaptic and mediate postsynaptic glutamatergic differentiation, with LRRTM1 and LRRTM2 most potent at inducing presynaptic differentiation. Each LRRTM protein is a type I transmembrane containing ten extracellular leucine-rich repeats and a short intracellular tail and has a developmentally regulated pattern distinct from all others. LRRTM2 interacts with PSD-95 and regulates the surface expression of AMPA receptors. LRRTM2 also functions as a neurexin ligand, binding both Neurexin 1-alpha and -beta, suggesting that LRRTM2-Neurexin1 interaction plays a critical role in regulatory excitatory synapse development
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing PBS with up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-LRRTM2 Antibody detects level of LRRTM2 & has been published & validated for use in LRRTM2.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: 2.5 μg/mL from a representative lot detected LRRTM2 in human brain tissue.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide corresponding to the cytoplasmic domain of human LRRTM2.
      Epitopecytoplasmic domain
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • LRRTM2
      • KIAA0416
      • LRRN2
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~65 kDa observed. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in SK-N-SH cell lysate with and without blocking peptide.

      Western Blotting Analysis: 1 μg/mL of this antibody detected LRRTM2 in SK-N-SH cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      ABN643 04053252946653