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MABF1096-100UG Anti-LRBA Antibody, clone 2D4.1

Anti-LRBA, clone 2D4.1 Antibody, Cat. No. MABF1096 is a mouse monoclonal antibody that detects Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.

Anti-LRBA Antibody, clone 2D4.1 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: LRBA, BGL, CDC4L, LBA UniProt Number: P50851
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MABF1096-100UG
100 μg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF1096-100UG
      DescriptionAnti-LRBA Antibody, clone 2D4.1
      Alternate Names
      • Lipopolysaccharide-responsive and beige-like anchor protein
      • Beige-like protein
      • CDC4-like protein
      Background InformationLipopolysaccharide-responsive and beige-like anchor protein (UniProt: P50851; also known as Beige-like protein, CDC4-like protein) is encoded by the LRBA (also known as BGL, CDC4L, LBA) gene (Gene ID: 987) in human. LRBA is a single-pass membrane protein that displays ubiquitous expression in normal tissues, but its expression is elevated in malignancy. In immune cells. It is found in all membrane compartments that are associated with receptor signaling, including the plasma membrane, Golgi complex, clathrin-coated pits, and trans-endocytic vesicles. Its expression is induced in B cells and macrophages by bacterial lipopolysaccharides (LPS). Two isoforms of LRBA have been reported that are produced by alternative splicing. LRBA contains 2 BEACH (Beige and Chediak-Higashi) domains and six WD repeats at its C-terminal. LRBA may be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. It coordinates signaling of immune receptors to promote effector function and plays a crucial role in immune regulation. Mutations in LRBA gene are associated with defective B-cell differentiation and decreased or absent antibody production. (Ref.: Park, MY et al. (2016). Nat. Scientific Reports 6:36568).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Applications
      ApplicationAnti-LRBA, clone 2D4.1 Antibody, Cat. No. MABF1096 is a mouse monoclonal antibody that detects Lipopolysaccharide-responsive and beige-like anchor protein (LRBA) and has been tested for use in Immunohistochemistry (Paraffin) and Western Blotting.
      Key Applications
      • Western Blotting
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected LRBA in human pancreas, human testis, and human cervical cancer tissue sections.
      Biological Information
      ImmunogenGST/His-tagged recombinant fragment corresponding to 115 amino acids from the N-terminal half of human Lipopolysaccharide-responsive and beige-like anchor protein (LRBA).
      Clone2D4.1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 2D4.1 detects human Lipopolysaccharide-responsive and beige-like anchor protein (LRBA). It targets an epitope within 115 amino acids from the N-terminal half.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LRBA
      • BGL
      • CDC4L
      • LBA
      Purification MethodProtein G purified
      UniProt Number
      Molecular Weight~320 kDa observed; 319.11 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in Jurkat cell membrane preparations.

      Western Blotting Analysis: 1 µg/mL of this antibody detected LRBA in 10 µg of Jurkat cell membrane preparations.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF1096-100UG 04054839482182