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MABF841 Anti-FCGR2A/C Antibody, clone 11B6

Anti-FCGR2A/C Antibody, clone 11B6 is an antibody against FCGR2A/C for use in Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blotting.

Anti-FCGR2A/C Antibody, clone 11B6 MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Research Sub-Category: Immunological Signaling Gene Symbol: CD32, FCG2, FCGR2A, FCGR2A1, FCGR2B, FCGR2C, IGFR2 UniProt Number: P12318, P31995
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MABF841
100 μg  
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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P), ICC, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF841
      DescriptionAnti-FCGR2A/C Antibody, clone 11B6
      Alternate Names
      • Low affinity immunoglobulin gamma Fc region receptor II-a
      • Low affinity immunoglobulin gamma Fc region receptor II-b
      • Low affinity immunoglobulin gamma Fc region receptor II-c
      • IgG Fc receptor II-a
      • IgG Fc receptor II-b
      • IgG Fc receptor II-c
      • CDw32
      • Fc-gamma RII-a
      • Fc-gamma RII-b
      • Fc-gamma RII-c
      • Fc-gamma-RIIa
      • Fc-gamma-RIIb
      • Fc-gamma-RIIc
      • FcRII-a
      • FcRII-b
      • FcRII-c
      • CD32
      Background InformationFcγRI/CD64, FcγRII/CD32, FcγRIII/CD16, and FcγRIV/CD16-2 represent the four known classes of IgG Fc receptors (FcγRs). FcγRII, FcγRIII, and FcγRIV are low-affinity receptors for monomeric IgG, whereas FcγRI is the only high-affinity FcγR. FcγRs play important roles in inflammatory cell activation, clearance, presentation of Ag, and maintenance of IgG homeostasis. In addition to binding immune complex (IC), FcγRs have been shown to bind non-IgG ligands. For example, FcγRII is shown to bind oxLDL, while FcγRIII binding to an E. coli component is reported to negatively regulate the function of macrophage receptor with collagenous structure (MARCO). FcyRII activation is also reported to transduce a negative regulatory signal against CD38 cross-linking-induced proliferation of resting mature B cells. Low affinity immunoglobulin gamma Fc region receptor II-a/b/c (IgG Fc receptor II-a/-b/-c, CDw32, Fc-gamma RII-a/-b/-c, Fc-gamma-RIIa/b/c, FcRII-a/-b/-c, CD32) are encoded by the FCGR2A/B/C (CD32, FCG2, IGFR2) genes in human (UniProt P12318, P31994, P31995; Gene ID 2212, 2213, 9103). The FcγRIIs encoded by the three genes are highly conserved in their extracellular portion, with significant variation in the transmembrane and intracellular regions. All three types of transcripts alternative splicing to generate additional isoforms.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal IgG1κ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-FCGR2A/C Antibody, clone 11B6 is an antibody against FCGR2A/C for use in Immunohistochemistry (Paraffin), Immunocytochemistry, Western Blotting.
      Key Applications
      • Immunohistochemistry (Paraffin)
      • Immunocytochemistry
      • Western Blotting
      Application NotesImmunocytochemistry Analysis: A representative lot detected FcγRIIc immunoreactivity in paraformaldehyde-fixed, Triton X-100-permeabilized human B cell lines carrying the FCGR2C-ORF allele, but not B cell lines with homozygous FCGR2C-STP alleles (Li, X., et al. (2013). Sci. Transl. Med. 5(216):216ra175).
      Western Blotting Analysis: A representative lot detected recombinant FcγRIIc cytoplasmic (CY) domain GST fusion, but not FcγRIIb CY domain GST fusion (Li, X., et al. (2013). Sci. Transl. Med. 5(216):216ra175).
      Biological Information
      ImmunogenLinear peptide corresponding to a cytoplasmic domain sequence identical in human FcγRIIa and FcγRIIc.
      EpitopeCytoplasmic domain.
      Clone11B6
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 11B6 recognizes human FcγRIIa and FcγRIIc, but not FcγRIIb, by targeting a conserved cytoplasmic domain sequence in human FcγRIIa and FcγRIIc.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD32
      • FCG2
      • FCGR2A
      • FCGR2A1
      • FCGR2B
      • FCGR2C
      • IGFR2
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight30.89 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human bone marrow tissue.

      Immunohistochemistry Analysis: An 1:50 dilution of this antibody detected FCGR2A/C in human bone marrow tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF841 04055977330328