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AB3830 Anti-Caveolin-1 Antibody, phospho-specific (Tyr14)

This Anti-Caveolin-1 Antibody, phospho-specific (Tyr14) is validated for use in IP, WB for the detection of Caveolin-1.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: CAV1, MSTP085, CAV, VIP21, Caveolin-1. UniProt Number: Q03135
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AB3830
100 µL  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, Mk, RIP, WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3830
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Caveolin-1 Antibody, phospho-specific (Tyr14)
      References
      Product Information
      FormatAffinity Purified
      PresentationProtein A and peptide affinity purified immunoglobulin. Liquid in 10 mM sodium HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA, with 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Caveolin-1 Antibody, phospho-specific (Tyr14) is validated for use in IP, WB for the detection of Caveolin-1.
      Key Applications
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blotting 1:1,000 (for best results, incubate membrane with diluted antibody in 5% BSA, 1X TBS, 0.1% Tween-20 at 4°C with gentle shaking, overnight)

      Immunoprecipitation 1:50

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenKLH-conjugated, synthetic phospho-peptide corresponding to residues surrounding Tyr14 of human caveolin-1
      Epitopephospho-specific (Tyr14)
      HostRabbit
      SpecificityRecognizes caveolin-1 only when phosphorylated at tyrosine 14. This antibody does not cross-react with caveolin-2, -3 or caveolin-1beta, or the short isoform of caveolin-1.
      Species Reactivity
      • Human
      • Mouse
      • Monkey
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe scaffolding protein encoded by this gene is the main component of the caveolae plasma membranes found in most cell types. The protein links integrin subunits to the tyrosine kinase FYN, an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. The gene is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 MAP kinase cascade. CAV1 and CAV2 are located next to each other on chromosome 7 and express colocalizing proteins that form a stable hetero-oligomeric complex. By using alternative initiation codons in the same reading frame, two isoforms (alpha and beta) are encoded by a single transcript from this gene.
      Gene Symbol
      • CAV1
      • MSTP085
      • CAV
      • VIP21
      • Caveolin-1.
      Modifications
      • Phosphorylation
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q03135 # May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity).
      SIZE: 178 amino acids; 20472 Da
      SUBUNIT: Homooligomer. Interacts with GLIPR2, NOSTRIN, SNAP25 and syntaxin.
      SUBCELLULAR LOCATION: Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane, caveola; Peripheral membrane protein; Cytoplasmic side. Note=Membrane protein of caveolae. Potential hairpin-like structure in the membrane.
      TISSUE SPECIFICITY: In muscle and lung, less so in liver, brain and kidney.
      PTM: The initiator methionine for isoform Beta is removed during or just after translation. The new N-terminal amino acid is then N-acetylated.
      SIMILARITY: SwissProt: Q03135 ## Belongs to the caveolin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20ºC for 12 months, do not aliquot.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      AB3830 04053252338694

      Documentation

      Anti-Caveolin-1 Antibody, phospho-specific (Tyr14) SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Caveolin-1 Antibody, phospho-specific (Tyr14) Certificates of Analysis

      TitleLot Number
      RABBIT ANTI- PHOSPHO-CAVEOLIN-1 (TYR14) - 3274287 3274287
      RABBIT ANTI- PHOSPHO-CAVEOLIN-1 (TYR14) POLYCLONAL ANTIBODY 3013578
      RABBIT ANTI- PHOSPHO-CAVEOLIN-1 (TYR14) POLYCLONAL ANTIBODY 2919158
      RABBIT ANTI- PHOSPHO-CAVEOLIN-1 (TYR14) POLYCLONAL ANTIBODY 2869801
      RABBIT ANTI- PHOSPHO-CAVEOLIN-1 (TYR14) POLYCLONAL ANTIBODY - 2343809 2343809

      Data Sheet

      Title
      RABBIT ANTI- PHOSPHO-CAVEOLIN-1 (TYR14) POLYCLONAL ANTIBODY

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies