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MABF360 Anti-CD117 (c-kit) Antibody (mouse), APC, clone ACK2

This rat monoclonal antibody Anti-CD117 (c-kit) (mouse), APC & clone ACK2 validated for use in western blotting;IHC;ICC;Flow Cytometry for the detection of CD117 (c-kit).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Inflammation & Immunology Gene Symbol: Kit, SI UniProt Number: P05532
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MABF360
100 µg  
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      Overview

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      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MWB, IHC, ICC, FCRAPCMonoclonal Antibody
      Description
      Catalogue NumberMABF360
      DescriptionAnti-CD117 (c-kit) Antibody (mouse), APC, clone ACK2
      Alternate Names
      • Mast/stem cell growth factor receptor Kit
      • SCFR
      • Proto-oncogene c-Kit
      • Tyrosine-protein kinase Kit
      • CD117
      Background InformationCD117, also called c-Kit, is a 145 kDa cytokine receptor important in the development of hematopoietic stem cells, in oogenesis, and for functional activity of immune cells such as NK and mast cells. c-Kit binds to a ligand known as stem cell factor (SCF), or alternatively as mast cell growth factor. Ligand binding promotes the activation (dimerization) and subsequent tyrosine kinase activity of the c-Kit receptor and triggers key survival, expansion and maturation signals during hematopoietic progenitor cell development. Conversely, shedding of extracellular domain of c-Kit receptor is reported to induce inactivation or apoptosis within these cells. The survival signaling activity of c-Kit confers a proto-oncogenic attribute to the receptor, as overexpression or mutations in this protein are associated with tumor development.
      References
      Product Information
      FormatAPC
      PresentationPurified rat monoclonal antibody in buffer containing 10 mM NaH2PO4, 150 mM NaCl, 0.1% gelatin, pH 7.2, and up to 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis rat monoclonal antibody Anti-CD117 (c-kit) (mouse), APC & clone ACK2 validated for use in western blotting;IHC;ICC;Flow Cytometry for the detection of CD117 (c-kit).
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      • Immunocytochemistry
      • Flow Cytometry
      Biological Information
      ImmunogenImmunogen information for this antibody is proprietary information.
      CloneACK2
      Concentration0.2 mg/mL
      HostRat
      SpecificityThis antibody is reported to be cross-reactive with rat CD117 and is extensively published for use in this species.
      IsotypeIgG2bκ
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • Kit
      • SI
      Purification MethodSize Exclusion Chromatography
      UniProt Number
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceThe monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.

      Flow Cytometry Analysis: 0.06 µg of this antibody detected CD117 in one million C57BI/6 bone marrow cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsIt is recommended to store the product undiluted at 2-8°C and protected from prolonged exposure to light. Do not freeze.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF360 04053252961786

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies