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MABF2319-100UG Anti-BLAST-2 (CD23) Antibody, clone EBVCS4

Anti-BLAST-2 (CD23), clone EBVCS4, Cat. No. MABF2319, is a mouse monoclonal antibody that detects Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) and is tesed for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation, and Radioimmunoassay.

MABF2319-100UG
100 μg  
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      Overview

      Replacement Information
      Description
      Catalogue NumberMABF2319-100UG
      DescriptionAnti-BLAST-2 (CD23) Antibody, clone EBVCS4
      Alternate Names
      • Low affinity immunoglobulin epsilon Fc receptor
      • C-type lectin domain family 4 member J
      • CD23
      • Fc-epsilon-RII
      • Immunoglobulin E-binding factor
      • Lymphocyte IgE receptor
      Background InformationLow affinity immunoglobulin epsilon Fc receptor (UniProt: P06734; also known as BLAST-2, C-type lectin domain family 4 member J, Fc-epsilon-RII, Immunoglobulin E-binding factor, Lymphocyte IgE receptor, CD23) is encoded by the FCER2 (also known as CD23A, CLEC4J, FCE2, IGEBF) gene (Gene ID: 2208) in human. Epstein-Barr virus (EBV) is reported to transform human B lymphocytes and is a causative agent for Burkitt s lymphoma and infectious mononucleosis. EBV induces the expression of one or more antigens (e.g., CD23) on the surface of adult human B-lymphocytes soon after infection. CD23 is a homotrimeric, single-pass type II membrane protein that serves as a low-affinity receptor for Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21 and plays an essential role in the regulation of IgE production and in the differentiation of B-cells. CD23 can also exist as a soluble excreted form, sCD23 (aa 150-321), which is produced by ADAM10-mediated ectoderm shedding. CD23 has a cytoplasmic domain (aa 1-21), a transmembrane domain (aa 22-47), and an extracellular domain (aa 48-321). Clone EBVCS4 can specifically detect antigens that are present on the surface of EBV-transformed cells. These antigens are also recognized by autochthonous cytotoxic T cells specific for EBV-transformed cells. (Ref.: Kintner, C., and Sugden, B. (1981). Nature. 294(3); 458-460).
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgM in PBS without preservatives.
      Applications
      ApplicationAnti-BLAST-2 (CD23), clone EBVCS4, Cat. No. MABF2319, is a mouse monoclonal antibody that detects Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) and is tesed for use in Flow Cytometry, Immunofluorescence, Immunoprecipitation, and Radioimmunoassay.
      Key Applications
      • Flow Cytometry
      • Immunofluorescence
      • Immunoprecipitation
      • Radioimmunoassay
      Application NotesRadioimmunoassay Analysis: A representative lot detected BLAST-2 (CD23) in Radioimmunoassay applications (Sugden, B., et. al. (1983). J Virol. 46(3):800-7).

      Immunofluorescence Analysis: A representative lot detected BLAST-2 (CD23) in Immunofluorescence applications (Kintner, C., et. al. (1981). Nature. 294(5840):458-60).

      Immunoprecipitation Analysis: A representative lot immunoprecipitated BLAST-2 (CD23) in Immunoprecipitation applications (Sugden, B., et. al. (1983). J Virol. 46(3):800-7).
      Biological Information
      ImmunogenEBV-transformed human cells.
      CloneEBVCS4
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone EBVCS4 is a mouse monoclonal antibody that specifically detects Low affinity immunoglobulin epsilon Fc receptor (BLAST-2) in human cells.
      IsotypeIgMκ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • FCER2
      • CD23A
      • CLEC4J
      • FCE2
      • IGEBF
      Purification MethodLigatrap
      UniProt Number
      Molecular Weight36.47 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in Raji B cells.

      Flow Cytometry Analysis: 2 µg of this antibody detected BLAST-2 (CD23) in one million Raji cells.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      MABF2319-100UG 04054839010545

      Documentation

      Anti-BLAST-2 (CD23) Antibody, clone EBVCS4 SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-BLAST-2 (CD23) Antibody, clone EBVCS4 Certificates of Analysis

      TitleLot Number
      Anti-BLAST-2 (CD23), clone EBVCS4 - Q3253074 Q3253074

      References

      Reference overviewPub Med ID
      Characterization of an antigen whose cell surface expression is induced by infection with Epstein-Barr virus.
      Sugden, B; Metzenberg, S
      J Virol  46  800-7  1983

      Show Abstract       		6304342 6304342
      Identification of antigenic determinants unique to the surfaces of cells transformed by Epstein-Barr virus.
      Kintner, C; Sugden, B
      Nature  294  458-60  1981

      Show Abstract       		6273741 6273741