124011 Sigma-AldrichAkt Inhibitor IV - CAS 681281-88-9 - Calbiochem
Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K.
More>> Akt Inhibitor IV, CAS 681281-88-9, is a cell permeable, reversible inhibitor of Akt phosphorylation that targets the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 681281-88-9 | C₃₁H₂₇IN₄S |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 124011-1MG |
|
Glass bottle | 1 mg |
|
— | |
| 124011-5MG |
|
Plastic ampoule | 5 mg |
|
— |
| Description | |
|---|---|
| Overview | A cell permeable and reversible benzimidazole compound that inhibits Akt phosphorylation/activation by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI 3-K. Shown to block Akt-mediated FOXO1a nuclear export (IC50 = 625 nM) and cell proliferation (IC50 <1.25 µM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors (Cat. Nos. 124005, 124008, 124009), this inhibitor does not affect PI3K. A 10 mM (1 mg/163 µl) solution of Akt Inhibitor IV (Cat. No. 124015) in DMSO is also available. |
| Catalogue Number | 124011 |
| Brand Family | Calbiochem® |
| References | |
|---|---|
| References | Kau, T.R., et al. 2003. Cancer Cell 4, 463. Selected Citations Lee, J., et al. 2009. Cell Stem Cell 5, 76. |
| Product Information | |
|---|---|
| CAS number | 681281-88-9 |
| ATP Competitive | N |
| Form | Yellow solid |
| Hill Formula | C₃₁H₂₇IN₄S |
| Chemical formula | C₃₁H₂₇IN₄S |
| Hygroscopic | Hygroscopic |
| Reversible | Y |
| Structure formula Image | |
| Quality Level | MQ100 |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 124011-1MG | 04055977206357 |
| 124011-5MG | 04055977205626 |