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SCC430 ALMC-1 Plasma Cell Myeloma Cell Line

The ALMC-1 plasma cell myeloma cell line is a clinically relevant model for amyloidosis and studying the mechanisms of myeloma progression.

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SCC430
≥1X10⁶ cells/vial   
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC430
      DescriptionALMC-1 Plasma Cell Myeloma Cell Line
      Alternate Names
      • ALMC1
      Background InformationPrimary systemic amyloidosis is a plasma cell disease characterized by deposition of misfolded immunoglobulin (Ig) light chain products as amyloid fibrils throughout vital tissues and organs. Amyloidosis may present as a range of symptoms, including nervous system dysfunction, swelling, fatigue, and pain in the extremities (1). Patients with amyloidosis often suffer from other plasma cell diseases such as multiple myeloma, making the study of amyloidosis and development of potential targeted treatments extremely challenging.

      ALMC-1 was the first plasma cell amyloidosis cell line isolated and is characterized by c-myc amplification and deletion of the tumor suppressor p53 (2). The Ig lambda secreted by ALMC-1 cells has been shown to form amyloid fibrils in vitro (2). ALMC-1 cells proliferate in presence of IL-6, a critical factor supporting tumor growth in the bone marrow microenvironment (2). ALMC-1 cells are hypotetraploid, express CD44, and overexpress the oncogene MAFB (2). The ALMC-1 plasma cell myeloma cell line represents a valuable and clinically relevant model for amyloidosis and studies of the mechanisms of myeloma progression.

      Source
      The ALMC-1 cell line was isolated from bone marrow of a 50-year old female patient with amyloidosis and later diagnosed with multiple myeloma (3).

      References
      1. J Am Coll Cardiol 2016; 68(12): 1323-1341.
      2. Blood 112 Suppl 2008; 1: 2732a-2832a.
      3. Cancer Res 1993; 53:5320-5327.
      References
      Product Information
      Quality LevelMQ100
      Applications
      ApplicationThe ALMC-1 plasma cell myeloma cell line is a clinically relevant model for amyloidosis and studying the mechanisms of myeloma progression.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEach vial contains ≥1X10⁶ viable cells.

      Cells are tested negative for infectious diseases by a Human Essential CLEAR panel by Charles River Animal Diagnostic Services.

      Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and Non-human Primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services

      Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC430 04065267912806