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504844 7-Chlorokynurenic Acid Sodium Salt - CAS 1263094-00-3 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

Synonyms: 7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt

Primary Target: NMDA receptors
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504844
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Overview

Key Spec Table

CAS #Empirical Formula
1263094-00-3C₁₀H₅ClNNaO₃

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      		 Glass bottle 10 mg
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      Description
      OverviewA very potent, water-soluble antagonist of the NMDA receptors complex acting at the strychnine-insensitive glycine binding site (IC50 = 0.56 µM). Also a potent inhibitor of glutamate transporter. Often used in studies of neuroprotection and schizophrenia.
      Catalogue Number504844
      Brand Family Calbiochem®
      Synonyms7-Chloro-4-hydroxyquinoline-2-carbo-xylic acid sodium salt
      References
      ReferencesKemp, J., et al. 1988. Proc. Natl. Acad. Sci. U.S.A. 85, 6550.
      Kretschmer, D., et al. 1995. Eur. J. Pharmacol. 280, 37.
      Bartlett, D., et al. 1999. Neuropharmacol. 37, 839.
      Moroni, F., et al. 1991. Eur. J. Pharmacol. 199, 32.
      Stone, W., et al. 2012. FEBS J. 279, 1386.
      Vécsei, L., et al. 2012. Nat. Rev. Drug Disc. 12, 64.
      Product Information
      CAS number1263094-00-3
      FormWhite solid
      Hill FormulaC₁₀H₅ClNNaO₃
      Chemical formulaC₁₀H₅ClNNaO₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetNMDA receptors
      Primary Target IC<sub>50</sub>0.56 →M
      Purity≥99% by HPLC
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Global Trade Item Number
      Catalogue Number GTIN
      5048440001 04055977243611