565770 Sigma-Aldrichγ-Secretase Inhibitor IX - CAS 208255-80-5 - Calbiochem
Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM).
More>> Gamma-Secretase Inhibitor IX - CAS 208255-80-5, is a cell-permeable inhibitor of γ-secretase (Aβtotal IC₅₀ = 115 nM, Aβ42 IC₅₀ = 200 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Synonyms: DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester
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Overview
Key Spec Table
| CAS # | Empirical Formula |
|---|---|
| 208255-80-5 | C₂₃H₂₆F₂N₂O₄ |
Pricing & Availability
| Catalogue Number | Availability | Packaging | Qty/Pack | Price | Quantity | |
|---|---|---|---|---|---|---|
| 565770-10MG |
|
Plastic ampoule | 10 mg |
|
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| 565770-5MG |
|
Glass bottle | 5 mg |
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| Description | |
|---|---|
| Overview | A cell-permeable dipeptide that suppresses Aβ production by blocking γ-secretase (Aβtotal IC50 = 115 nM, Aβ42 IC50 = 200 nM). Prevents Aβ34 generation in murine N2a cells and hAPP/hBACE-1 transfected human HEK 293 cells. Reported to be functionally active in both HEK 293 cells and neuronal cultures without affecting the secretion of amyloid-β precursor protein (APP). Also shown to lower Aβ levels acutely in APP-transgenic mice. Reported to reduce extracellular Aβ plaques and intracellular Aβ accumulation in 3xTgAD transgenic mice. A 25 mM (5 mg/462 µl) solution of γ-Secretase Inhibitor IX (Cat. No. 565784) in DMSO is also available. |
| Catalogue Number | 565770 |
| Brand Family | Calbiochem® |
| Synonyms | DAPT, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester |
| Product Information | |
|---|---|
| CAS number | 208255-80-5 |
| ATP Competitive | N |
| Form | Lyophilized |
| Hill Formula | C₂₃H₂₆F₂N₂O₄ |
| Chemical formula | C₂₃H₂₆F₂N₂O₄ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
|---|---|
| Primary Target | Aβtotal |
| Primary Target IC<sub>50</sub> | 115 nM suppressing Aβtotal production; 200 nM suppressing Aβ42 production |
| Purity | ≥98% by HPLC |
| Physicochemical Information | |
|---|---|
| Cell permeable | Y |
| Packaging Information | |
|---|---|
| Packaged under inert gas | Packaged under inert gas |
| Global Trade Item Number | |
|---|---|
| Catalogue Number | GTIN |
| 565770-10MG | 04055977267778 |
| 565770-5MG | 07790788059941 |