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324517 eIF4E/eIF4G Interaction Inhibitor, 4EGI-1 - CAS 315706-13-9 - Calbiochem

324517
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Overview

Key Spec Table

CAS #Empirical Formula
315706-13-9C₁₈H₁₂Cl₂N₄O₄S

Products

Catalogue NumberPackaging Qty/Pack
324517-10MG Plastic ampoule 10 mg
Description
OverviewA cell-permeable hydrazone compound that reversibly binds eukaryotic translation initiation factor 4E (eIF4E; KD = 25 µM) and disrupts eIF4E/eIF4G, but not eIF4E/4E-BP1, complex formation. Reported to downregulate the protein, but not mRNA, levels of c-Myc and Bcl-xL in Jurkat cells (8 h), leading to apoptotic cell death after prolonged exposure (24 h, IC50 = ~ 25 µM). Also available as a 25 mM solution in DMSO (Cat. No. 324519).
Catalogue Number324517
Brand Family Calbiochem®
Synonyms2-((4-(3,4-Dichlorophenyl)-thiazol-2-ylhydrazono)-3-(2-nitrophenyl))propionic acid, eIF4F Inhibitor I
References
ReferencesMoerke, N. J., et al. 2007. Cell 128, 257.
Product Information
CAS number315706-13-9
FormYellow solid
Hill FormulaC₁₈H₁₂Cl₂N₄O₄S
Chemical formulaC₁₈H₁₂Cl₂N₄O₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationeIF4E/eIF4G Interaction Inhibitor, 4EGI-1, CAS 315706-13-9, is a cell-permeable compound that reversibly binds eIF4E (KD = 25 µM) and disrupts eIF4E/eIF4G complex formation.
Biological Information
Purity≥98% by HPLC (sum of two isomers)
Safety Information
R PhraseR: 22

Harmful if swallowed.
S PhraseS: 36-45

Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
324517-10MG 04055977197327