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676496 VEGF Inhibitor, CBO-P11 - Calbiochem

676496
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Overview

Key Spec Table

Empirical Formula
C₉₀H₁₄₀N₂₈O₂₂S

Products

Catalogue NumberPackaging Qty/Pack
676496-1MG Plastic ampoule 1 mg
Description
OverviewA macrocyclic 17-amino acid peptide derived from residues 79 - 93 of vascular endothelial growth factor that mediate its binding to VEGFR-2. It blocks the binding of VEGF165 to its receptors (IC50 = 700 nM for VEGFR1, 1.3 µM for VEGFR2) and exhibits anti-angiogenic activity as well as other VEGFR-mediated cellular functions, such as proliferation (IC50 = 5.8 µM), migration (IC50 = 8.2 µM), and activation of MAP kinases. Its anti-angiogenic activity has been successfully demonstrated in vivo using chick embryos and nude mice tumor models of human intracranial and syngeneic glioma.
Catalogue Number676496
Brand Family Calbiochem®
SynonymsCyclo-VEGI, cyclic(D-F-PQIMRIKPHQGQHIGE), D-Phe-Pro(79-93), VEGFR Tyrosine Kinase Inhibitor XX, VEGFR2 Kinase Inhibitor XVI
References
ReferencesZilberberg, L., et al. 2003. J. Biol. Chem. 278, 35564.
Product Information
ATP CompetitiveN
FormWhite lyophilized solid
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₉₀H₁₄₀N₂₈O₂₂S
Chemical formulaC₉₀H₁₄₀N₂₈O₂₂S
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
ApplicationVEGF Inhibitor, CBO-P11, is a macrocyclic peptide derived from residues 79-93 of VEGF. Mediates VEGF binding to VEGFR-2. Blocks VEGF165 binding to VEGFR1 and 2 (IC50 = 700 nM & 1.3 µM, respectively).
Biological Information
Primary TargetBlocks the binding of VEGF165 to its receptors
Primary Target IC<sub>50</sub>700 nM for VEGFR1, 1.3 µM for VEGFR2
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide Sequencecyclic(D-Phe-Pro-Gln-Ile-Met-Arg-Ile-Lys-Pro-His-Gln-Gly-Gln-His-Ile-Gly-Glu)
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
Catalogue Number GTIN
676496-1MG 04055977260489