Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

572630 SU5402 - CAS 215543-92-3 - Calbiochem

572630
Purchase on Sigma-Aldrich

Overview

Key Spec Table

CAS #Empirical Formula
215543-92-3C₁₇H₁₆N₂O₃

Products

Catalogue NumberPackaging Qty/Pack
572630-1MG Plastic ampoule 1 mg
572630-2MG Glass bottle 2 mg
572630-500UG Plastic ampoule 500 μg
Description
OverviewA cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available.
Catalogue Number572630
Brand Family Calbiochem®
Synonyms3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
References
ReferencesMohammadi, M., et al. 1997. Science 276, 955.
Product Information
CAS number215543-92-3
ATP CompetitiveY
DeclarationNot available for sale in the United States.
FormLyophilized solid
Hill FormulaC₁₇H₁₆N₂O₃
Chemical formulaC₁₇H₁₆N₂O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ200
Biological Information
Primary TargetFibroblast growth factor receptor 1 (FGFR1)
Primary Target IC<sub>50</sub>10-20 &10-20 µM for fibroblast growth factor receptor 1 (FGFR1) in the presence of 1 mM ATP;M against FGFR1 in the presence of 1 mM ATP; 10-20 µM against inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Global Trade Item Number
Catalogue Number GTIN
572630-1MG 04055977266207
572630-2MG 04055977266238
572630-500UG 04055977266269