572630 Sigma-AldrichSU5402 - CAS 215543-92-3 - Calbiochem
SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP).
More>> SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC₅₀ = 10-20 µM in the presence of 1 mM ATP). Less<<Synonyms: 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone
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Overview
Key Spec Table
CAS # | Empirical Formula |
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215543-92-3 | C₁₇H₁₆N₂O₃ |
Products
Catalogue Number | Packaging | Qty/Pack | |
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572630-1MG | Plastic ampoule | 1 mg | |
572630-2MG | Glass bottle | 2 mg | |
572630-500UG | Plastic ampoule | 500 μg |
Description | |
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Overview | A cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of fibroblast growth factor receptor 1 (FGFR1; IC50 = 10-20 µM in the presence of 1 mM ATP). Also inhibits aFGF-induced tyrosine phosphorylation of ERK1 and ERK2 (IC50 = 10-20 µM). In contrast to SU4984 (Cat. No. 572625), SU5402 is only a weak inhibitor of tyrosine phosphorylation of the PDGF receptor and does not inhibit phosphorylation of the insulin receptor. Does not inhibit the kinase activity of the EGF receptor. A 10 mM (500 µg/169 µl) solution of SU5402 (Cat. No. 572631) in DMSO is also available. |
Catalogue Number | 572630 |
Brand Family | Calbiochem® |
Synonyms | 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone |
References | |
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References | Mohammadi, M., et al. 1997. Science 276, 955. |
Product Information | |
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CAS number | 215543-92-3 |
ATP Competitive | Y |
Declaration | Not available for sale in the United States. |
Form | Lyophilized solid |
Hill Formula | C₁₇H₁₆N₂O₃ |
Chemical formula | C₁₇H₁₆N₂O₃ |
Reversible | Y |
Structure formula Image | |
Quality Level | MQ200 |
Physicochemical Information | |
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Cell permeable | Y |
Global Trade Item Number | |
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Catalogue Number | GTIN |
572630-1MG | 04055977266207 |
572630-2MG | 04055977266238 |
572630-500UG | 04055977266269 |